Issue 2-84, 2018

Experience in Use of Neuromodulators in Early Recovery Period of Ischemic Stroke

1 Novak E.V., 1 Uvarova O.A., 1 Daminov V.D.

1 The National Medical and Surgical Center n.a. N.I. Pirogov, Moscow, Russia


The cost-effectiveness of modern rehabilitation is determined not only by functional outcome per se but also by thetime needed to reach some progress. The aim of the present study was to investigate how neuropeptides added to conventionalrehabilitation can accelerate the recovery of lower extremities movements in chronic stroke.The research was monocentric randomized placebo-controlled. Patients in both groups received exercises and robotic-assisted walking therapy and intravenous infusion of 30ml Cerebrolysin® (EVER Pharma) in the study group (40patients) or isotonic solution in the control group (40 patients) for 14 continuous days.Both groups demonstrated significant improvement measured by 36-Item Short Form Survey Instrument (36-SF),Rivermead Index Mobility (RIM) and Functional Independence Measure (FIM) while the modified Rankin Scale (mRS)did not reveal statistical change in the degree of disability. The mean RIM score was 6 in both groups on the 14th day,however, required time for such outcome assessed by survival analysis was 13 days in the study group in comparison to14 days in the control group. The difference was statistically significant (Wilcoxon signed-rank test Т=–3,198; р=0,001).The results of this study indicated probable benefits of adding neuropeptides to conventional rehabilitation that couldfacilitate recovery process and shorten time needed for expected motor improvement in chronic stroke.

KEYWORDS: chronic stroke, motor rehabilitation, neuropeptides


Creative Commons License
The content is available under the Creative Commons Attribution 4.0 License.


This is an open article under the CC BY 4.0 license. Published by the National Medical Research Center for Rehabilitation and Balneology.