Issue №5-87, 2018

Structural Mechanisms of Kidneys Functional Ssystems Integration in the Regulation of Protein Homeostasis

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1 Chinieva M.I.

1 Tashkent pediatric medical institute


ABSTRACT

To decryption the mechanisms of kidneyshomeostatic functions, integration of functional systems that provide its worka model of protein loading in different age periodswasmade. However, structural mechanisms of interaction between differentfunctional systems of kidney in different physiological conditions remains poorly understood. This led to the aim ofthe study – to identify the structural basis of kidneysfunctional systems integrationin the regulation of protein homeostasis.In the experiment carried out on white rats, we studied the morphology of the kidney tissue by morphometric and electronmicroscopic methods in protein load (15 rats), protein starvation (15 rats) and in control (15 rats). The kidneys tissuecorresponding to the superficial and juxtamedullary nephrons, were studied on the first, third and seventh day of the experiment,after fixation in a 2.5% solution of buffered glutaraldehyde acid.It is shown that on 1 day of protein load activation of juxtaglomerular apparatus(JGA) cells wasobservedwith a gradualdecrease in activity by 3 day, whereas during protein starvation, the activation of JGAwas not observed. Herewith, bothexperimental groups showed an increase in the proportion of glomeruliwith a greater degree of blood capillariesopening.However, at protein load, these changes persisted up to 7 days of observation, as at protein starvation after 7 days the degreeof blood capillaries opening remained high only in juxtamedullary nephrons. In control ratscondition of juxtaglomerular apparatusand degree of blood capillaries openingindicate moderate functional activity of kidneys.The authors come to the conclusion that at different physiological conditions logical changes of juxtaglomerular apparatuscellsand capillaries of superficial and juxtamedullary nephronsglomerulioccur, which aims to increase the functionalreserve of kidneys.


KEYWORDS: kidney, homeostasis, protein load, protein homeostasis, renal function, structural integration, functional systems, glomerular filtration rate, juxtaglomerular apparatus



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This is an open article under the CC BY 4.0 license. Published by the National Medical Research Center for Rehabilitation and Balneology.