Issue 2-20, 2020
Modern approaches to the treatment and rehabilitation of patients with facial neuropathy
1 Zavaliy L.B., 1,2 Petrikov S.S., 1 Ramazanov G.R., 2 Kasatkin D.S., 1 Chekhonatskaya K.I.
1 N.V. Sklifosovsky Research Institute of Emergency Medicine, Mosсow, Russian Federation
2 A.I. Evdokimov Moscow State University of Medicine and Dentistry, Moscow, Russian Federation
ABSTRACT
Facial nerve neuropathy can manifest itself with gross organic and functional disorders. The esthetic defect worsenssocial adaptation and quality of life. However, there is no consensus, protocol or algorithm of treatment of the patientwith this pathology. In article we present a modern way of treatment and rehabilitation of patients with neuropathy ofa facial nerve of various etiology. Conservative and surgical types of treatment are applied during the different periodsof a disease. Surgical methods of treatment can be divided into two groups: reconstructive, decompressive and alsoplastic. The choice of a type of operation is defined individually with many factors, including an etiology and time ofa disease. Both the new and tested by time techniques are applied. Conservative therapy includes corticosteroids,antiviral, antibacterial drugs depending on a clinical situation. Traditionally specialists of policlinics and hospitals appointadditional therapy (group B vitamins, cholinesterase inhibitors, antioxidants, neuroprotectors, nootropic drugs), however single small researches couldn’t enforce these drugs recommendations. Botulinum toxin type A is effective in the acuteand chronic periods of a disease. Depending on a clinical situation of botulinum toxin type A are injected both in affected,and in healthy part of the face. Patients with incomplete eye closure are given keratoprotection as early as possible, andblepharography is performed in case of pronounced deficit. As an alternative method, botulinum toxin type A injectionsare used into the upper eyelid lifting muscle. One of the most effective methods of rehabilitation of patients with facialnerve neuropathy is therapeutic physical education such as neuromuscular retraining with biological feedback. The mostoptimal combination is the injection of botulinum toxin type A and therapeutic physical education.
KEYWORDS: facial nerve, facial neuropathy, Bell palsy, facial asymmetry, botulinum therapy, botulinum toxin type A, rehabilitation, Kabat
FOR CITATION: Zavaliy L.B., Petrikov S.S., Ramazanov G.R., Kasatkin D.S., Chekhonatskaya K.I Modern approaches to the treatment and rehabilitation of patients with facial neuropathy. Bulletin of rehabilitation medicine. 2020; 96 (2): 59-67. https://doi.org/10.38025/2078-1962-2020-96-2-59-67
References:
- Klinicheskij protokol medicinskoj pomoshhi pacientam s nejropatiej licevogo nerva [Clinical protocol of medical care for patients with facial neuropathy]. Moskva, Associacija cheljustno-licevyh hirurgov i hirurgov-stomatologov, 2014. Available at: https://chlgvv.ru/media/media/documents/2018/10/12/ kl_prot_neir_lic_nerva.pdf
- Kleiss I.J., Beurskens C.H., Stalmeier P.F., Ingels K.J., Marres H.A. Quality of life assessment in facial palsy: validation of the Dutch Facial Clinimetric Evaluation Scale. Eur Arch Otorhinolaryngol. 2015; 272(8): 2055-2061. DOI: 10.1007/s00405-015-3508-x
- Ivanova G.E., Zajcev O.S., Maksakova O.A., Prokopenko S.V., Ivanova N.E. Organizacionnye aspekty obespechenija vosstanovlenija psihicheskoj dejatel'nosti v processe nejroreabilitacii [Aspects of the organization of ensuring the restoration of mental activity in the process of neurorehabilitation]. Vestnik vosstanovitel'noj mediciny. 2018; 2(84): 37-40 (In Russ.).
- Finkensieper M., Volk G.F., Guntinas-Lichius O. Facial nerve disorders. Laryngorhinootologie. 2012; 91(2): 121-142. DOI: 10.1055/s-0031-1300965
- Lorch M., Teach S.J. Facial nerve palsy: etiology and approach to diagnosis and treatment. Pediatr Emerg Care. 2010; 26(10): 763-769. DOI: 10.1097/ PEC.0b013e3181f3bd4a
- Spencer C.R., Irving R.M. Causes and management of facial nerve palsy. Br J Hosp Med (Lond). 2016; 77(12): 686-691. DOI: 10.12968/hmed.2016.77.12.686
- Markin S.P. Porazhenija licevogo nerva (patogenez, terapija) [Facial nerve lesions (pathogenesis, therapy)]. Zhurnal nevrologii im. B.M. Man'kovskogo. 2017; 5(1): 65-70 (In Russ.).
- Holland J., Bernstein J. Bell's palsy. BMJ Clin Evid. 2011; 2011: 1204.
- Peitersen E. Bell’s palsy: the spontaneous course of 2,500 peripheral facial nerve palsies of different etiologies. Acta Otolaryngol Suppl. 2002; (549): 4-30.
- Cardoso J.R., Teixeira E.C., Moreira M.D., Favero F.M., Fontes S.V., Bulle de Oliveira A.S. Effects of exercises on Bell's palsy: systematic review of randomized controlled trials. Otol Neurotol. 2008; 29(4): 557-560. DOI: 10.1097/MAO.0b013e31816c7bf1
- de Almeida J.R., Guyatt G.H., Sud S., Dorion J., Hill M.D., Kolber M.R., Lea J., Reg S.L., Somogyi B.K., Westerberg B.D., White C., Chen J.M. Management of Bell palsy: clinical practice guideline. CMAJ. 2014; 186(12): 917-922. DOI: 10.1503/cmaj.131801
- Zvonikov V.M., Krupnova A.B. Vzaimosvjaz' urovnja psihojemocional'nogo naprjazhenija s pokazateljami motornyh i sensornyh funkcional'nyh asim-metrij u lic «opasnyh professij» [The relationship of the level of psycho-emotional stress with indicators of motor and sensory functional asymmetries in persons of “dangerous professions”]. Vestnik vosstanovitel'noj mediciny. 2016; 5(75): 78-81 (In Russ.).
- van Landingham S.W., Diels J., Lucarelli M.J. Physical therapy for facial nerve palsy: applications for the physician. Curr Opin Ophthalmol. 2018; 29(5): 469-475. DOI: 10.1097/ICU.0000000000000503
- Banks C.A., Jowett N., Azizzadeh B., Beurskens C., Bhama P., Borschel G., Coombs C., Coulson S., Croxon G., Diels J., Fattah A., Frey M., Gavilan J., Henstrom D., Hohman M., Kim J., Marres H., Redett R., Snyder-Warwick A., Hadlock T. Worldwide testing of the eFACE facial nerve clinician-graded scale. Plast Reconstr Surg. 2017; 139(2): 491e-498e. DOI: 10.1097/prs.0000000000002954
- Zavaliy L.B., Petrikov S.S., Ramazanov G.R., Chehonackaja K.I. Botulinoterapija pri nevropatii licevogo nerva. [Botulinum therapy for facial neuropathy]. Rossijskij nevrologicheskij zhurnal. 2020;25(1): 23-28 (In Russ.). DOI: 10.30629/2658-7947-2020-25-1-23-28
- Zhuleva N.M. Nevropatii: rukovodstvo dlja vrachej [Neuropathy: a guide for doctors], Sankt-Peterburg, SPbMAPO, 2005 (In Russ.).
- Axelsson S., Berg T., Jonsson L., Engstrom M., Kanerva M., Pitkaranta A., Stjernquist-Desatnik A. Prednisolone in Bell's palsy related to treatment start and age. Otol Neurotol. 2011; 32(1): 141-146. DOI: 10.1097/MAO.0b013e3182009f35
- Hastings J.C., Peacock E.E. Effect of injury, repair, and ascorbic acid deficiency on collagen accumulation in peripheral nerves. Surg Forum. 1973; 24: 516-519.
- Lexer E., Eden R. Uber die chirurgische Behandlung der peripheren. Facialislahmung [About the surgical treatment of the peripheral. Facial paralysis]. Beitr Klin Chir. 1911; 73: 116.
- Gantz B.J., Rubinstein J.T., Gidley P., Woodworth G.G. Surgical management of Bell's palsy. Laryngoscope. 1999; 109(8): 1177-1188. DOI: 10.1097/00005537199908000-00001
- Atlas of Surgery of the Facial Nerve: An Otolaryngologists Perspective. 2nd ed. London: Jaypee Brotherss Medical Publishers Ltd; 2012.
- Karjagina M.V., Ivanova N.E., Tereshin A.E., Oljushin V.E., Vjazgina E.M., Makarov A.O., Efimova M.Ju. Rezul'taty hirurgicheskogo lechenija dobrokachest-vennyh opuholej golovnogo mozga posle vtorogo jetapa reabilitacii [Results of surgical treatment of benign brain tumors after the second stage of rehabilitation]. Vestnik vosstanovitel'noj mediciny. 2016; 5(75): 6-11 (In Russ.).
- Grinshtejn A.B. Nevrit licevogo nerva [Facial neuritis], Novosibirsk, Nauka, 1980 (In Russ.).
- Garro A., Nigrovic L.E. Managing Peripheral Facial Palsy. Ann Emerg Med. 2018; 71(5): 618-624. DOI: 10.1016/j.annemergmed.2017.08.039
- Engstrom M., Berg T., Stjernquist-Desatnik A., Axelsson S., Pitkaranta A., Hultcrantz M., Kanerva M., Hanner P., Jonsson L. Prednisolone and valaciclovir in Bell’s palsy: a randomised, double-blind, placebocontrolled, multicentre trial. Lancet Neurol. 2008; 7(11): 993-1000. DOI: 10.1016/S1474-4422(08)70221-7
- Sullivan F.M., Swan I.R., Donnan P.T., Morrison J.M., Smith B.H., McKinstry B., Davenport R.J., Vale L.D., Clarkson J.E., Hammersley V., Hayavi S., McAteer A., Stewart K., Daly F. Early treatment with prednisolone or acyclovir in Bell’s palsy. N Engl J Med. 2007; 357(16): 1598-1607. DOI: 10.3310/hta13470
- Furuta Y., Takasu T., Sato K.C., Fukuda S., Inuyama Y., Nagashima K. Latent herpes simplex virus type 1 in human geniculate ganglia. Acta Neuropathol. 1992; 84(1): 39-44. DOI: 10.1007/bf00427213
- Rahman I., Sadiq S.A. Ophthalmic management of facial nerve palsy: a review. Surv Ophthalmol. 2007; 52(2): 121-144. DOI: 10.1016/j.survoph-thal.2006.12.009
- Portelinha J., Passarinho M.P., Costa J.M. Neuro-ophthalmological approach to facial nerve palsy. Saudi J Ophthalmol. 2015; 29(1): 39-47. DOI: 10.1016/j. sjopt.2014.09.009
- Svistushkin V.M., Slavskij A.N. Nevropatija licevogo nerva: sovremennye podhody k diagnostike i lecheniju [Facial neuropathy: modern approaches to diagnosis and treatment]. RMZh. 2016; 4: 280-285 (In Russ.).
- Artjushkevich A.S., Ruman G.M., Adashhik N.F., Bajda A.G. Klinika, diagnostika i lechenie nevropatij licevogo nerva [Clinic, diagnosis and treatment of facial neuropathy]. Sovremennaja stomatologija. 2015; 2: 23-28 (In Russ.).
- Jalaludin M.A. Methylcobalamin treatment of Bell's palsy. Methods Find Exp Clin Pharmacol. 1995; 17(8): 539-544.
- Mijnhout G.S., Kollen B.J., Alkhalaf A., Kleefstra N., Bilo H.J. Alpha Lipoic Acid for Symptomatic Peripheral Neuropathy in Patients with Diabetes: A MetaAnalysis of Randomized Controlled Trials. Int J Endocrinol. 2012; 2012: 456279. DOI: 10.1155/2012/456279
- Batysheva T.T., Kostenko E.V., Bojko A.N. Kompleksnoe lechenie nevropatii licevogo nerva s primeneniem nejromidina i antioksidantnoj terapii [Complex treatment of facial neuropathy with the use of neuromidine and antioxidant therapy]. Psihiatrija i psihofarmakologija. 2004; 6(4): 199-202 (In Russ.).
- Tungcan T., Yalcin J., Demir C.F., Akin M.M., Karlidag T., Kele? E., Kaygusuz i. Efficacy of Cortexin and Methylprednisolone on Traumatic Facial Nerve Paralysis. J Int Adv Otol. 2016; 12(3): 303-309. DOI: 10.5152/iao.2016.1166
- Guntinas-Lichius O., Streppel M., Stennert E. Postoperative functional evaluation of different reanimation techniques for facial nerve repair. Am J Surg. 2006; 191(1): 61-67. DOI: 10.1016/j.amjsurg.2005.05.054
- Anonsen C.K., Trachy R.E., Hibbert J., Cummings C.W. Assessment of facial reinnervation by use of chronic electromyographic monitoring. Otolaryngol Head Neck Surg. 1986; 94: 32-36. DOI: 10.1177/019459988609400105
- Guntinas-Lichius O., Irintchev A., Streppel M., Lenzen M., Grosheva M., Wewetzer K., Neiss W.F., Angelov D.N. Factors limiting motor recovery after facial nerve transection in the rat: combined structural and functional analyses. Eur J Neurosci. 2005; 21(2): 391-402. DOI: 10.1111/j.1460-9568.2005.03877.x
- Eccles J.C., Libet B., Young R.R. The behaviour of chromatolysed motoneurones studied by intracellular recording. J Physiol. 1958; 143(1): 11-40. DOI: 10.1113/jphysiol.1958.sp006041
- Lieberman A.R. The axon reaction: a review of the principal features of perikaryal responses to axon injury. Int Rev Neurobiol. 1971; 14: 49-124. DOI: 10.1016/s0074-7742(08)60183-x
- Cooper L., Lui M., Nduka Ch. Botulinum toxin treatment for facial palsy: A systematic review. J Plast Reconstr Aesthet Surg. 2017; 70(6): 833-841. DOI: 10.1016/j.bjps.2017.01.009
- Kim J. Contralateral botulinum toxin injection to improve facial asymmetry after acute facial paralysis. Otol Neurotol. 2013; 34(2): 319-324. DOI: 10.1097/ mao.0b013e31827c9f58
- Salles A.G., Toledo P.N., Ferreira M.C. Botulinum toxin injection in long-standing facial paralysis patients: Improvement of facial symmetry observed up to 6 months. Aesthetic Plast Surg. 2009; 33(4): 582-590. DOI: 10.1007/s00266-009-9337-9
- de Maio M., Bento R.F. Botulinum Toxin in Facial Palsy: An Effective Treatment for Contralateral Hyperkinesis. Plast Reconstr Surg. 2007; 120(4): 917-927. DOI: 10.1097/01.prs.0000244311.72941.9a
- Akulov M.A., Tanjashin S.V., Shimanskij V.N., Usachev D.Ju., Orlova O.R., Zaharov V.O., Karnauhov V.V., Kolycheva M.V., Hat'kova S.E., Latysheva N.V., Orlova A.S. Jeffektivnost' botulinoterapii v lechenii otsrochennoj nejropatii licevogo nerva posle udalenija nevrinomy sluhovogo nerva [The effectiveness of botulinum therapy in the treatment of delayed facial neuropathy after removal of the auditory nerve neuroma]. Zhurnal voprosy nejrohirurgii im. N.N. Burdenko. 2018; 5: 81-87 (In Russ.).
- Borodic G., Martley M., Slattery W., Glasscock M., Johnson E., Malazio C., Goodnough M., Acquadro M., McKenna M.. Botulinum toxin for aberrant facial nerve regeneration: double-blind, placebo controlled trial using subjective endpoints. Plast Reconstr Surg. 2005; 116(1): 36-43. DOI: 10.1097/01. prs.0000169689.27829.c4
- Choi K.H., Rho S.H., Lee J.M., Jeon J.H., Park S.Y., Kim J. Botulinumtoxin injection of both sides of the face to treat post-paralytic facial synkinesis. J Plast Reconstr Aesthet Surg. 2013; 66(8): 1058-1063. DOI: 10.1016/j.bjps.2013.04.012
- Monini S., de Carlo A., Biagini M., Buffoni A., Volpini L., Lazzarino A.I., Barbara M. Combined protocol for treatment of secondary effects from facial nerve palsy. Acta Otolaryngol. 2011; 131(8): 882-886. DOI: 10.3109/00016489.2011.577447
- do Nascimento Remigio A.F., Salles A.G., de Faria J.C., Ferreira M.C. Comparison of the Efficacy of OnabotulinumtoxinA and AbobotulinumtoxinA at the 1:3 Conversion Ratio for the Treatment of Asymmetry after Long-Term Facial Paralysis. Plast Reconstr Surg. 2015; 135(1): 239-249. DOI: 10.1097/ prs.0000000000000800
- Barbara M., Antonini G., Vestri A., Volpini L., Monini S. Role of Kabat physical rehabilitation in Bell’s palsy: a randomized trial. Acta Otolaryngol. 2010; 130(1): 167-172. DOI: 10.3109/00016480902882469
- Zavaliy L.B., Ramazanov G.R., Petrikov S.S., Dzhagraev K.R., Chehonackaja K.I., Gadzhieva Zh.H. Klinicheskij sluchaj lechenija povrezhdenija licevogo i trojnichnogo nervov u pacientki s koloto-rezanym raneniem shei [A clinical case of treatment of damage to the facial and trigeminal nerves in a patient with a stab-cut neck wound]. Consilium Medicum. 2019; 21 (9): 54-57 (In Russ.). DOI: 10.26442/20751753.2019.9.190370
- Wen C.M., Zhang B.C. Effect of rehabilitation training at different degree in the treatment of idiopathic facial palsy: a randomized controlled comparison. Zhongguo Linchuang Kangfu. 2004; 8(13): 2446-2447.
- Beurskens C.H., Heymans P.G. Mime therapy improves facial symmetry in people with long-term facial nerve paresis: a randomized controlled trial. Aust J Physiother. 2006; 52(3): 177-183. DOI: 10.1016/s0004-9514(06)70026-5
- Belkin A.A., Avdjunina I.A., Varako N.A., Zinchenko Ju.P., Voznjuk I.A., Davydova N.S., Zabolotskih I.B., Ivanova G.E., Kondrat'ev A.N., Lejderman I.N., Lubnin A.Ju., Petrikov S.S., Piradov M.A., Procenko D.N., Stahovskaja L.V., Suvorov A.Ju., Suponeva N.A., Shamalov N.A., Shhegolev A.V. Reabilitacija v intensivnoj terapii. Klinicheskie rekomendacii. [Rehabilitation in intensive care. Guideline]. Vestnik vosstanovitel'noj mediciny. 2017; 2: 139-141 (In Russ.).
- Kabat H. Proprioceptive facilitation in therapeutic exercise. In: Licht S., ed. Therapeutic exercise. Baltimore, MD: Waverly Press; 1958.Vol. 4.
- Kabat H., McLeod M., Holt C. The practical application of proprioceptive neuromuscular facilitation. Physiotherapy. 1959; 45(4): 87-92.
- Barbara M., Monini S., Buffoni A., Cordier A., Ronchetti F., Harguindey A., Di Stadio A., Cerruto R., Filipo R. Early Rehabilitation of Facial Nerve Deficit after Acoustic Neuroma Surgery. Acta Otolaryngol. 2003; 123(8): 932-935. DOI: 10.1080/00016480310000629
- Manikandan N. Effect of facial neuromuscular re-education on facial symmetry in patients with Bell’s palsy: a randomized controlled trial. Clin Rehabil. 2007; 21(4): 338-343. DOI: 10.1177/0269215507070790
- Monini S., Iacolucci C.M., Di Traglia M., Lazzarino A.I., Barbara M. Role of Kabat rehabilitation in facial nerve palsy: a randomised study on severe cases of Bell’s palsy. Acta Otorhinolaryngol Ital. 2016; 36(4): 282-288. DOI: 10.14639/0392-100X-783
- Diels H.J., Combs D. Neuromuscular retraining for facial paralysis. Clin Otolaryngol. 1997; 30(5): 727-743.
- Farragher D.J. Electrical stimulation: a method of treatment for facial paralysis. In: Rose F.C., Jones R., Vrbova G., eds. Neuromuscular stimulation: basic concepts and clinical implication. New York: Demos; 1989: 303-306. Vol.3.
- Kasahara T., Ikeda S., Sugimoto A., Sugawara S., Koyama Y., Toyokura M., Masakado Y. Efficacy of tape feedback therapy on synkinesis following severe peripheral facial nerve palsy. Tokai J Exp Clin Med. 2017; 42(3): 139-142.
- Grishhenko S.V., Nadtochij A.G., Malickaja O.A. Monitoring sostojanija tkanej shhechno-skulovoj oblasti posle lipofilinga na jetapah reabilitacii [Monitoring the state of tissues of the buccal-zygomatic region after lipofilling at the stages of rehabilitation]. Vestnik vosstanovitel'noj mediciny. 2015; 2(66): 7-13 (In Russ.).
- Navarrete M.L., Palao R., Torrent L., Fuentes J.F., Gonzalez M. Facial Asymmetry Correction in Facial Palsy Patients with Silhouette Sutures. Int J Clin Med. 2012; 3(1): 55-59. DOI: 10.4236/ijcm.2012.31012
- Azuma T., Nakamura K., Takahashi M., Ohyama S., Toda N., Iwasaki H., Kalubi B., Takeda N. Mirror biofeedback rehabilitation after administration of singledose botulinum toxin for treatment of facial synkinesis. Otolaryngol Head Neck Surg. 2012; 146(1): 40-45. DOI: 10.1177/0194599811424125
- Lee J.M., Choi K.H., Lim B.W., Kim M.W., Kim J. Half-mirror biofeedback exercise in combination with three botulinum toxin A injections for long-lasting treatment of facial sequelae after facial paralysis. J Plast Reconstr Aesthet Surg. 2015; 68(1): 71-78. DOI: 10.1016/j.bjps.2014.08.067
- Mandrini S., Comelli M., Dall’Angelo A., Togni R., Cecini M., Pavese C., Dalla Toffola E. Long-term facial improvement after repeated BoNTA injections and mirror biofeedback exercises for chronic facial synkinesis: a case-series study. Eur J Phys Rehabil Med. 2016; 52(6): 810-818.
- Bezuglyj A.P. Diagnostika oslozhnenij posle vvedenija intradermal'nyh fillerov metodom vysokochastotnogo ul'trazvukovogo skanirovanija v prak-tike dermatologa i kosmetologa [Monitoring the state of tissues of the buccal-zygomatic region after lipofilling at the stages of rehabilitation]. Vestnik vosstanovitel'noj mediciny. 2015; 4(68): 73-76 (In Russ.).
- Sahan A., Tamer F. Restoring facial symmetry through non-surgical cosmetic procedures after permanent facial paralysis: a case report. Acta Dermato-venerol Alp Pannonica Adriat. 2017; 26(2): 41-42. DOI: 10.15570/actaapa.2017.12

The content is available under the Creative Commons Attribution 4.0 License.
©
This is an open article under the CC BY 4.0 license. Published by the National Medical Research Center for Rehabilitation and Balneology.