Issue 4-98, 2020

Original article

https://doi.org/10.38025/2078-1962-2020-98-4-48-54

Influence the Baths of Bishophite on Indicators of Protein S100B in Blood in Children with Autistic Spectrum Disorders

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1 ORCIDGolubova T.F., 2 ORCIDTsukurova L.A., 1 ORCIDNuvoli A.V., 1 ORCIDVlasenko S.V., 3 ORCIDSavchuk E.A.

1 Scientific Research Institute of Children’s Balneology, Physiotherapy and Medical Rehabilitation, Yevpatoria, Russian Federation
2 Kubansky Medical Institute, Krasnodar, Russian Federation
3 V.I. Vernadsky Crimean Federal University, Simferopol, Russian Federation


ABSTRACT

The aim of the study was to study the effect of bishovite baths on the dynamics of plasma S100B protein in children withautism spectrum disorders (ASD).Material and methods. 45 children with autism (F84) aged from 6 to 15 years were examined – general croup (GG). The controlgroup (KG) consisted of 25 healthy children. I group – 22 children who received the health research therapy (HRT); II group – 23children who received a course of the baths with bishophite. The examination included examination by specialists, an assessmentof the severity of the disease using the CARS scale (Children’s Rating Scale of Autism), evaluation in blood serum of protein S100B.Results. The content of S100B in children with autism was significantly higher in comparison with KG. The level of S100B inchildren with ASD with abnormal development of brain structures (MRI) was significantly higher in comparison with KG andwith a group of children without signs of violation of brain structures. With hard ASD the S100B indicators were higher, andat medium severity did not differ significantly from the KG. After the treatment only in the II group, there was a significantdecrease in S100B in GG in children with abnormalities in the development of the brain and with severe severity.Conclusions. The majority of children with ASD with anomalies of brain structures, there are signs of hypoxia of the brainand violation of the blood-brain barrier. A positive effect of bischophite baths was revealed in children with ASD, havingantioxidant, antitoxic, and neuroprotective effects.


KEYWORDS: autism, children, CARS (Children’s Rating Scale of Autism), S100B protein, violation of the blood-brain barrier, bath with bishophite, the health research therapy

FOR CITATION: Golubova T.F., Tsukurova L.A., Nuvoli A.V., Vlasenko S.V., Savchuk E.A. Influence the Baths of Bishophite on Indicators of Protein S100B in Blood in Children with Autistic Spectrum Disorders. Bulletin of Rehabilitation Medicine. 2020; 4 (98): 48–54. https://doi.org/10.38025/2078-1962-2020-98-4-48-54


References:

  1. Vetchinkina Yu.V., Skoromec A.P. Poisk biomarkerov cerebral’noj gipoksii u novorozhdennyh [Search for biomarkers of cerebral hypoxia in newborns]. Izvestiya Komi nauchnogo centra UrO RAN. 2013; 1(13): 56-62 (In Russ.).
  2. Skoromec A.A., Dambinova S.A., D’yakonov M.M., Granstrem O.K., Bileckij P.S., Sedova O.A., Skoromec A.P., Smolko D.G., Hunteev G.V., SHikuev A.V., SHumilina M.V. Biohimicheskie markery v diagnostike ishemii golovnogo mozga [Biochemical markers in the diagnosis of cerebral ischemia]. Mezhdunarodnyj nevrologicheskij zhurnal. 2009; 5(27):15-20 (In Russ.).
  3. Dvorak F., Haberer I., Sitzer M., Foerch C. Characterisation of the diagnostic window of serum glial fibrillary acidic protein for the differentiation of intracerebral haemorrhage and ischaemic stroke. Cerebrovascular Diseases. 2009; 27(1): 37-41. DOI:10.1159/000172632
  4. Michetti F., Corvino V., Geloso M.C., Lattanzi W., Bernardini C., Serpero L., Gazzolo D. The S100B protein in biological fluids: more than a lifelong biomarker of brain distress. Journal of Neurochemistry. 2012; 120(5): 644-659. DOI:10.1111/j.1471- 159.2011.07612.x
  5. Donato R., Sorci G., Riuzzi F., Arcuri C., Bianchi R., Brozzi F., Tubaro C., Giambanco I. S100B’s double life: Intracellular regulator and extracellular signal. Biochimica et Biophysica Acta (BBA). Molecular Cell Research. 2009; 1793(6): 1008-1022. DOI:10.1016/j.bbamcr.2008.11.009
  6. Hakimova G.R., Voronina T.A., Dugina Yu.L., Ertuzun I.A., Epshchtejn O.I. Spektr farmakologicheskih effektov antitel k belku S 100 v realiz-aktivnoj forme i mekhanizmy ih realizacii [The spectrum of pharmacological effects of antibodies to protein S 100 in a real-active form and mechanisms for their implementation]. Zhurnal nevrologii i psihiatrii. 2016; (4):100-113. DOI:10.17116/jnevro201611641100-113 (In Russ.).
  7. Pavlushkina L., CHernevskaya E., Dmitrieva I., Beloborodova N. Bio-markery v klinicheskoj praktike [Bio-markers in clinical practice]. Poliklinika. 2013; (3): 10-14 (In Russ.).
  8. Rothermundt M., Peters M., Prehn J.H., Arolt V. S100B in brain damage and neurodegeneration. Microscopy Research and Technique. 2003; 60(6): 614-32. DOI:10.1002/jemt.10303
  9. Golosnaya G.S., Petruhin A.S., Markevich K.A., Trifonova O.E. Izmenenie urovnya belka S-100 u novorozhdennyh s perinatal’nym gipoksicheskim porazheniem CNS [Change in the level of S-100 protein in newborns with perinatal hypoxic damage to the central nervous system]. Pediatriya. 2004; (1): 1-6 (In Russ.).
  10. Serikova I.Yu., Vorob’eva E.N., Shumaher G.I. Immunobiohimicheskie markery porazheniya nervnoj sistemy u podrostkov s otdalennymi posledstviyami perinatal’noj patologii CNS [Immunobiochemical markers of nervous system damage in adolescents with long-term consequences of perinatal CNS pathology]. Zhurnal sibirskih medicinskih nauk. 2014; (2): 1-7 (In Russ.).
  11. Vink R. Magnesium in the CNS: recent advances and developments. Magnesium Research. 2016; 29(3): 95-101. DOI:10.1684/mrh.2016
  12. Tuner R.J., Vink R., Nishizawa Y., Morii H., Durlach J. Magnesium in the Central Nervous System. New perspectives in magnesium research. Springer. 2006: 338-353. DOI:10.1007/978-84628-483-0_28
  13. Han M.A, CHubarova A.I., Degtyareva M.G., Kuyanceva L.V., Tulenkova T.E., Mikitchenko N.A. Tekhnologii medicinskoj reabilitacii i abilitacii detej s posledstviyami perinatal’noj patologii nervnoj sistemy. [Technologies for medical rehabilitation and habilitation of children with consequences of perinatal pathology of the nervous system]. Bulletin of Rehabilitation Medicine. 2018; 3(85): 53-57 (In Russ.).
  14. Vladimirov A.A., Ezhov V.V., Ponomarenko G.N. Fizioterapiya [Physiotherapy]. K. Format. 2013; (1): 310-322 (In Russ.).
  15. Llojd E., Lederman U., Tyurin Yu.N. Spravochnik po prikladnoj statistike [Handbook of Applied Statistics]. M. Finansy i statistika. 1989-1990; (1): 266 p.; (2): 211 p. (In Russ.).
  16. Poletaev A.B. Antitela k antigenam nervnoj tkani i patologiya nervnoj sistemy. [Antibodies to antigens of nervous tissue and pathology of the nervous system]. Vestnik «MEDSI». 2011; (3): 14-21 (In Russ.).



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This is an open article under the CC BY 4.0 license. Published by the National Medical Research Center for Rehabilitation and Balneology.