Issue 6-20, 2021

Review article

https://doi.org/10.38025/2078-1962-2021-20-6-84-95

Development of Wound Dressing for Regenerative Medicine

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1 ORCIDIrina S. Kudryashova, 1 ORCIDPavel A. Markov, 1 ORCIDElena Yu Kostromina, 1 ORCIDPetr S. Eremin, 1 ORCIDAndrey P. Rachin, 1 ORCIDIlmira R. Gilmutdinova

1 National Medical Research Center of Rehabilitation and Balneology, Moscow, Russian Federation


ABSTRACT

The understanding of the pathophysiological mechanisms of the wound process deepened with the development of science. The technological base that was creating has enabled to serve the clinical needs of tissue repair. These factors, combined with the growing need for healing of infected and chronic wounds, have led to the expansion of the market for wound dressings materials supplies. In this connection, there is a need to generalize and update information about new types of dressings.

This review provides an up-to-date understanding of the wound process: cellular and signaling mechanisms of repair, characteristics of the optimal microclimate of the wound bed, morphofunctional re-arrangements of tissues during the healing process. Based on these data, the requirements for the modern wound dressings are formulated. Existing wound dressings have been classified as interacting with body tissue. The bio-functional characteristics of the synthetic and natural polymers used in the dressing are described, including their effect on regenerative processes. A classification of the active medicinal ingredients used in the manufacture of dressings is given, the characteristics of their use on the background of the pathological wound process are considered.


KEYWORDS: wound dressing, wound process, interactive wound dressing, bioactive wound dressing, biomaterials, wound treatment

FUNDING: The study had no sponsorship

CONFLICT OF INTEREST: The authors declare no apparent or potential conflicts of interest related to the publication of this article

FOR CITATION: Kudryashova I.S., Markov P.A., Kostromina E.Yu., Eremin P.S., Rachin A.P., Gilmutdinova I.R. Development of Wound Dressing for Regenerative Medicine. Bulletin of Rehabilitation Medicine. 2021; 20 (6): 84-95. https://doi.org/10.38025/2078-1962-2021-20-6-84-95

FOR CORRESPONDENCE:

Irina S. Kudryashova, e-mail: Irinzha@gmail.com


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This is an open article under the CC BY 4.0 license. Published by the National Medical Research Center for Rehabilitation and Balneology.