Issue №5-21, 2022
Health Resort Detox Programs Impact on the Body: a Prospective Laboratory Analysis in «Kivach Clinic»
1 Fedor I. Isayev, 2,3 Alexey A. Moskalev
1 Kivach Clinic, Konchezero Republic of Karelia, Russian Federation
2 Komi Research Centre of the Russian Academy of Sciences, Syktyvkar, Russian Federation
3 National Medical and Surgical Center named after N.I. Pirogov, Moscow, Russian Federation
ABSTRACT
INTRODUCTION. The impact on a human organism of health resort detox programs based on therapeutic governance of lymphatic tissues drainage on human metabolism and a possibility to reduce intoxication and inflammation level has not been evaluated yet.
AIM. To make the first attempt to objectively estimate the influence of health resort body detoxification programs on lipid and carbohydrate metabolism and the processes of intoxication and inflammation.
MATERIAL AND METHODS. The laboratory data were obtained for all the patients treated under the detoxication program in the corresponding date range (89 persons had a venous blood collected on the first day and the day before the departure). The dynamics of the laboratory indicators were calculated.
RESULTS AND DISCUSSION. There is an increase of intoxication markers to the end of the first week and a decrease of inflammation and intoxication markers to the end of the second accompanied by a decrease in total cholesterol level. HOMA decreases in all groups, but other insulin resistance markers remain unaltered.
The decrease in cholesterol confirms the expected effect of lymphatic drainage and bile acid loss. There is a decrease in the hepatic insulin resistance without a significant change of the total one. The process of autointoxication rising during the lymphatic drainage and its further decline below the start values is confirmed.
CONCLUSION. An attempt was made to evaluate the body's detoxification programmes using laboratory markers. Such programs decrease level of total cholesterol, body’s intoxication and inflammation level, lower hepatic component of the insulin resistance. This impact is in stages.
KEYWORDS: environmental pollutants, sorption detoxification, health resorts, lipid metabolism, carbohydrate metabolism, inflammation, insulin resistance
For citation: Isayev F.I., Moskalev A.A. Health Resort Detox Programs Impact on the Body: a Prospective Laboratory Analysis in «Kivach Clinic». Bulletin of Rehabilitation Medicine. 2022; 21 (5): 109-115. https://doi.org/10.38025/2078-1962-2022-21-5-109-115
References:
- Cakala-Jakimowicz M., Kolodziej-Wojnar P., Puzianowska-Kuznicka M. Aging-Related Cellular, Structural and Functional Changes in the Lymph Nodes: A Significant Component of Immunosenescence? An Overview. Cells. 2021; 10(11): 3148 p. https://doi.org/10.3390/cells10113148
- Levin Ju.M., Buchin V.N., Bykov A.T. et al. Endoecological medicine and experimental therapy. Moscow. 2000: 343 p.
- Filelfi S.L., Onorato A., Brix B., Goswami N. Lymphatic Senescence: Current Updates and Perspectives. Biology. 2021; 10(4): 293 p. https://doi.org/10.3390/biology10040293
- Manisalidis Ioannis, Stavropoulou Elisavet, Stavropoulos Agathangelos, Bezirtzoglou Eugenia. Environmental and Health Impacts of Air Pollution: A Review. Frontiers in Public Health. 2020; (8): 14 p. https://doi.org/10.3389/fpubh.2020.00014
- Rashtian J., Chavkin D.E., Merhi Z. Water and soil pollution as determinant of water and food quality/contamination and its impact on female fertility. Reproductive Biology and Endocrinology. 2019; (17). https://doi.org/10.1186/s12958-018-0448-5
- Grunig G., Marsh L.M., Esmaeil N., Jackson K., Gordon T., Reibman J., Kwapiszewska G., Park S.H. Perspective: ambient air pollution: inflammatory response and effects on the lung's vasculature. Pulmonary Circulation. 2014; 4(1): 25-35. https://doi.org/10.1086/674902
- Tara M. Wallace, Jonathan C. Levy, David R. Matthews. Use and Abuse of HOMA Modeling. Diabetes Care. 2004; 27(6): 1487-1495. https://doi.org/10.2337/diacare.27.6.1487
- Yoon J., Jung D., Lee Y., Park B. The Metabolic Score for Insulin Resistance (METS-IR) as a Predictor of Incident Ischemic Heart Disease: A Longitudinal Study among Korean without Diabetes. Journal of Personalized Medicine. 2021; 11(8): 742 p. https://doi.org/10.3390/jpm11080742
- Hong S., Han K., Park C.Y. The triglyceride glucose index is a simple and low-cost marker associated with atherosclerotic cardiovascular disease: a population-based study. BMC Medicine. 2020; (18): 361. https://doi.org/10.1186/s12916-020-01824-2
- Speranskij I.I., Samojlenko G.E., Lobacheva M.V. Are all the possibilities of a blood differential test exhausted? Integral intoxication indices are cri-terions of an endogenous intoxication course severity, its complication and treatment efficiency evaluation. Acute and emergency conditions in practitioner’s practice. 2009; 6(19): 3-12.
- Bychkova M.V., Trusov D.V., Kuljucina E.R., Pochinina N.K. Informativity of leukocyte parameters and erythrocyte sedimentation rate as indicators of chronic endogenous intoxication in the dynamics of hospital treatment of patients with chronic rhinosinusitis and chronic tonsillitis. Effective pharmacotherapy. 2020; 16(37): 6-13.
- Chiang J.Y.L., Ferrell J. M. Bile Acids as Metabolic Regulators and Nutrient Sensors. Annual Review of Nutrition. 2019; (39): 175-200. https://doi.org/10.1146/annurev-nutr-082018-124344
- Sato R. Recent advances in regulating cholesterol and bile acid metabolism. Bioscience, Biotechnology & Biochemistry. 2020; 84(11): 2185-2192. https://doi.org/10.1080/09168451.2020.1793658
- Lavrenova E.A., Drapkina O.M. Insulin resistance in obesity: causes and consequences. Obesity and Metabolism. 2020; 17(1): 48-55. https://doi.org/10.14341/omet9759
- Petersen M.C., Shulman G.I. Mechanisms of Insulin Action and Insulin Resistance. Physiological Reviews. 2018; 98(4): 2133-2223. https://doi.org/10.1152/physrev.00063.2017
- Akira Katsuki, Yasuhiro Sumida, Esteban C. Gabazza, Shuichi Murashima, Masahiko Furuta, Rika Araki-Sasaki, Yasuko Hori, Yutaka Yano, Yukihiko Adachi. Homeostasis Model Assessment Is a Reliable Indicator of Insulin Resistance During Follow-up of Patients With Type 2 Diabetes. Diabetes Care. 2001; 24 (2): 362-365. https://doi.org/10.2337/diacare.24.2.362
- Schteingart D.E., McKenzie A.K., Victoria R.S., Tsao H.S. Suppression of insulin secretion by protein deprivation in obesity. Metabolism. 1979; 28(9): 943-949. https://doi.org/10.1016/0026-0495(79)90095-7
- Jesaulova T.A. Hematological markers of intoxication as an indicator of a chronic intoxication of Astrahan gas complex workers. Fundamental Investigations. 2008; (6): 120 p.
- Geltser B.I., Dej A.A., Titorenko I.N., Kotelnikov V.N. Comparative analysis of the strength of the respiratory muscles in community-acquired pneumonia with different severity of endogenous intoxication. Therapeutic Archive. 2020; 3(92): 19-24. https://doi.org/10.26442/00403660.2020.03.000372
- Zaripova T.N., Antipova I.I., Titskaya E.V. Leukocyte indices of patients with bronchial asthma: informative significance of use. Therapeutic Archive. 2021; 93(3): 273-278. https://doi.org/10.26442/00403660.2021.03.200653
- Levchenko K.F., Chernobaj G. N. The informativity of standard paraclinical test in patients with breast cancer. Novosibirsk State University Herald. Biology and Clinical Medicine Series. 2010; 8(1): 150-154
- Saranchina Ju.V. Integral leucocyte indices as markers of endogenous intoxication in Helicobacter pylori – associated gastritis. Eurasian Scientific Union. 2017; 2(24): 80-84.
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This is an open article under the CC BY 4.0 license. Published by the National Medical Research Center for Rehabilitation and Balneology.