Issue №6-21, 2022

https://doi.org/10.38025/2078-1962-2022-21-6-52-58

Dynamics of Indicators of the Fetoplacental Complex during Ozone Therapy: a Prospective Comparative Study of 93 Women with Acute Serous Gestational Pyelonephritis

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1 ORCIDMarina R. Gaitova, 2,3 ORCIDAndrei A. Fedorov, 4,5 ORCIDAgnessa S. Kaisinova, 4 ORCIDMesrop A. Mkrtchyan, 2 ORCIDMikhail A. Frank, 4 ORCIDNatalya V. Efimenko

1 City clinical hospital № 40, Yekaterinburg, Russian Federation
2 Urals State Medical University, Yekaterinburg, Russian Federation
3 Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Yekaterinburg, Russian Federation
4 North Caucasian Federal Scientific and Clinical Center of the Federal Medical and Biological Agency, Essentuki, Russian Federation
5 Pyatigorsk Medical and Pharmaceutical Institute, a branch of Volgograd State Medical University, Pyatigorsk, Russian Federation


ABSTRACT

INTRODUCTION. The beneficial effect of the ozone therapy use in acute serous gestational pyelonephritis is well-known. However, in the scientific literature there is no information on the effect of medical ozone on the functional state of placental fetal blood flow with this pathology.

AIM. To study the dynamics of fetoplacental complex parameters in women suffering from acute serous gestational pyelonephritis using ozone-oxygen mixture.

MATERIAL AND METHODS. The studies were conducted on 93 pregnant women at the age of 28 (16-39) years old suffering from acute serous gestational pyelonephritis, gestational age was from 14 to 26 weeks, who were randomized into two groups: the first/study (n=46) group and the second/control (n=47) one. The control group of pregnant women took only the drug standard according to the Federal Clinical Guidelines. In the study group, drug therapy was supplemented by intravenous administration of an ozone-oxygen mixture. Both groups were evaluated in the dynamics of ultrasound examination of the fetoplacental complex, as well as uterine and placental blood flow Dopplerometry.

DISCUSSION. The increase in the effectiveness of restorative treatment of women with acute serous gestational pyelonephritis including ozone therapy is due to an increase in the initially reduced diastolic blood perfusion rate; summation of the therapeutic effects of ozone and pharmacotherapy; enhancement of pharmacopotential value of the used medicinal preparation.

CONCLUSION. Parenteral application of ozone-oxygen mixture in programs of restorative treatment of women with acute serous gestational pyelonephritis provides significant improvement of functional state of placental-uterine blood flow.


KEYWORDS: serous, acute gestational pyelonephritis, ozone therapy, pregnancy complications

For citation: Gaitova M.R., Fedorov A.A., Kaisinova A.S., Mkrtchyan M.A., Frank M.A., Efimenko N.V. Dynamics of Indicators of the Fetoplacental Complex during Ozone Therapy: a Prospective Comparative Study of 93 Women with Acute Serous Gestational Pyelonephritis. Bulletin of Rehabilitation Medicine. 2022; 21 (6): 52-58. https://doi.org/10.38025/2078-1962-2022-21-6-52-58



References:

  1. Shkodkin S.V. Pyelonephritis in pregnant women: where to start? Urology Herald. 2019; 7(3): 41-46. https://doi.org/10.21886/2308-6424-2019-7-3-41-46 (In Russ.).
  2. Cunningham F.G., Lucas M.J. Urinary tract infections complicating pregnancy. Baillière's Clinical Obstetrics and Gynaecology. 1994; (8): 353-373. https://doi.org/10.1016/s0950-3552(05)80325-6
  3. Kozak Yu.V., Kiseleva T.V., Pekarev O.G., Pozdnyakov I.M. Application of Extracorporal Methods of Detoxicating at Treatment of Pregnant Women with Acute Gestational Pyelonephrites. Journal of Siberian Medical Sciences. 2012; (1). (In Russ.).
  4. Şimşir A., Kızılay F., Semerci B. Comparison of percutaneous nephrostomy and double J stent in symptomatic pregnancy hydronephrosis treatment. Turkish Journal of Medical Sciences. 2018; 48(2): 405-411. https://doi.org/10.3906/sag-1711-5
  5. Lokshin K.L. Upper urinary tract draining in acute gestational pyelonephritis: What for? When? For how long? Urology Herald. 2019; 7(3): 35-40. https://doi.org/10.21886/2308-6424-2019-7-3-35-40 (In Russ.).
  6. Wang T., Wu G., Wang J., Cui Y., Ma J. et al. Comparison of Single-dose Fosfomycin Tromethamine and Other Antibiotics for Lower Uncomplicated Urinary Tract Infection in Women and Asymptomatic Bacteriuria in Pregnant Women: a systematic review and meta-analysis. International Journal of Antimicrobial Agents. 2020; 56 (1): 106018. https://doi.org/10.1016/j.ijantimicag.2020.106018
  7. Asmat U., Mumtaz M. Z., Malik A. Rising prevalence of multidrug-resistant uropathogenic bacteria from urinary tract infections in pregnant women. Journal of Taibah University Medical Sciences. 2020: 16(1): 102-111. https://doi.org/10.1016/j.jtumed.2020.10.010 
  8. Plekhanov A.A., Khvorostukhina N.F., Stepanova N.N., Satueva E.Ya., Mamedova M.M. The Influence of Gestational Pyelonephritis on the Course and Outcome of Pregnancy. Modern Problems of Science and Education. 2018; (4): 128 p. (In Russ.).
  9. Satueva E.Ya., Mamedova M.M. Acute gestational pyelonephritis and its impact on the course and outcome of pregnancy. Medical Conferences Online. 2018; 8(5): 192-193 (In Russ.).
  10. Khardikov A.V., Petrov S.V., Lyadvin A.Yu. Relationship between placental-fetal blood flow and nuclear index of intoxication in uncomplicated pyelonephritis in pregnant women. Medicina. 2016; 3(15): 40-44 (In Russ.).
  11. Naboka Y.L., Ryma- shevskij A.N., Kogan O.M., Gudima I.A., Vorob'eva N.V., Al'kina A.K. Asymptomatic bacteriuria and pyelonephritis during pregnancy. Medical Herald of the South of Russia. 2021; 12(3): 22-31. https://doi.org/10.21886/2219-8075-2021-12-3-22-31 (In Russ.).
  12. Zhigunova A.K. The use of uroantiseptics in the treatment of diseases of the urinary system during pregnancy. Health of Woman. 2014; 1(93): 72-78 (In Russ.).
  13. Khuraseva A.B., Petrov S.V. Phytoprophylaxis of infectious complications of gestation in women with chronic pyelonephritis. Medical Alphabet. 2019; 1(1): 76-79. https://doi.org/10.33667/2078-5631-2019-1-1(376)-76-79 (In Russ.).
  14. Grette K., Cassity S., Holliday N., Rimawi B.H. Acute pyelonephritis during pregnancy: a systematic review of the aetiology, timing, and reported adverse perinatal risks during pregnancy. Journal of Obstetrics and Gynaecology. 2020; 40(6): 739-748. https://doi.org/10.1080/01443615.2019.1647524
  15. Ponomarenko G.N. Physical and Rehabilitation Medicine: National Guidelines. Moscow. GEOTAR-Media. 2020: 688 p. (In Russ.).
  16. Kastueva N.D., Czallagova L.V., Merdenova L.A., Majsuradze L.V. The role of new medical technologies in obstetrics and gynecology. Modern Issues of Biomedicine. 2018; 2(3): 132-145 (In Russ.).
  17. Fedorova T.A., Mixajlova O.I., Tyutyunnik V.L., Bakuridze E.M., Vinogradova M.A. Experience in the use of medical ozone in the complex therapy of placental insufficiency. Biradicals and Antioxidants. 2016; 3(3): 176-179 (In Russ.).
  18. Gaitova M.R., Fedorov A.A., Frank M.A. The effectiveness of complex treatment with the inclusion of ozone therapy for acute gestational pyelonephritis. Resort Medicine. 2021; (1): 54-59.



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