Issue №6-21, 2022

https://doi.org/10.38025/2078-1962-2022-21-6-68-77

Complex Use of B-Luron Supplement in Knee Osteoarthrosis: a Prospective Randomized Study

View article (Download PDF file)



Download XML file

1 ORCIDVladimir Yu. Ulyanov, 1 ORCIDNatalya A. Romakina, 1 ORCIDTatyana Yu. Kalyuta, 1 ORCIDAngelina A. Yurkovets, 1 ORCIDAleksandr S. Fedonnikov

1 Saratov State Medical University named after V.I. Razumovsky, Saratov, Russia Federation


ABSTRACT

INTRODUCTION. Knee osteoarthrosis (KO) among the adult population often leads to permanent disability, a sharp decrease in the quality of life, and chronic use of analgesics. At the same time, according to the clinical guidelines of the Russian Rheumatology Association for osteoarthrosis treatment, hyaluronic acid medications are included in the list recommended for KO, and they are particularly effective at stages I-II of the disease.

AIM. Evaluation of the efficiency of the dietary supplement B-Luron for KO patients within 12 weeks therapy.

MATERIAL AND METHODS. A total of 70 patients with stage I-II deforming osteoarthrosis (DOA) were followed up, consecutively included in the study from December 14, 2021 to January 31, 2022, for an average of 90 days (3 months).

RESULTS AND DISCUSSION. The efficiency of B-Luron for I-II DOA stages was shown: a statistically significant decrease in the level of pain in knee joints, an improvement in the function of the joint were found compared to the initial state. The analysis of objective data showed a positive trend in ultrasound parameters and MRI features of joint inflammation and a decrease in the need for analgesics within 12 weeks.

CONCLUSION. In a prospective randomized clinical trial with 70 knee DOA patients as a part of the combination therapy (12 weeks use) with non-steroidal anti-inflammatory drugs, B-Luron showed its efficiency for stages I-II of the disease; there was a positive trend in ultrasound parameters and MRI signs of inflammation in the joints as well as a decrease in the need for non-steroidal anti-inflammatory drug use.


KEYWORDS: arthrosis of the knee joint, osteoarthritis, B-Luron, hyaluronic acid preparations, analgesics, quality of life

For citation: Ulyanov V.Yu., Romakina N.A., Kalyuta T.Yu., Yurkovets A.A., Fedonnikov A.S. Complex use of B-Luron Supplement in Knee Osteorathrosis: A Prospective Randomized Study. Bulletin of Rehabilitation Medicine. 2022; 21 (6): 68-77. https://doi.org/10.38025/2078-1962-2022-21-6-68-77



References:

  1. Kellgren J.H., Lawrence J.S. Radiological assessment of osteo-arthrosis. Annals of the Rheumatic Diseases. 1957; 16(4): 494-502. https://doi.org/10.1136/ard.16.4.494
  2. Korzh N.A., Bolkhovitin P.V. Diagnostic criteria for early osteoarthritis of the knee. Available at: http://health-ua.com/article/6728-diagnosticheskie-kriterii-rannego-osteoartroza-kolenno- go-sustava (accessed 06.12.2022) (In Russ.).
  3. Clinical criteria for knee OA. Available at: https://www.invalidnost.com/index/osteoartroz/0-204 (accessed 06.12.2022) (In Russ.).
  4. Interpretation of BMI indicators (according to WHO recommendations). Available at: https://medicalc.ru/indeksmassytela (accessed 06.12.2022) (In Russ.).
  5. Chon- droitini sulfas. Russian Drug Registry. Available at: https://www.rlsnet.ru/active-substance/xondroitina-sulfat-985 (accessed 06.12.2022) (In Russ.).
  6. Acidum hyaluronicum. Russian Drug Registry. Available at: https://www.rlsnet.ru/active-substance/gialuronovaya-kislota-2858 (accessed 06.12.2022) (In Russ.).
  7. Vitamin E. Russian Drug Registry. Available at: https://www.rlsnet.ru/drugs/vitamin-e-alfa-tokoferola-acetat-69221#dejstvuyush- hee-veshhestvo (accessed 06.12.2022) (In Russ.).
  8. Magnitskaya N.E., Ryazantsev M.S., Maisigov M.N., Logvinov A.N., Zaripov A.R., Korolev A.V. Translation, validation and cultural adaptation of orthopaedic questionnaire IKDC 2000 subjective knee form to measure knee function. Genij Ortopedii. 2019; 25(3): 348-354. https://doi.org/10.18019/1028-4427-2019-25-3-348-354 (In Russ.).
  9. Kopylova D.A., Ostapenko V.A. Correlation between clinical manifestations of ostheoarthritis and fluc- tuating blood levels of interleukin 6. Scientific and Practical Rheumatology. 2012; 54(5): 34-36 (In Russ.).
  10. EQ-5D: Russian version for Russia. Available at: https://spb.hse.ru/data/2020/03/10/1563014698/EQ-5D-3L.pdf (accessed 06.12.2022) (In Russ.).
  11. Briggs A.M., Woolf A.D., Dreinhöfer K., Homb N., Hoy D.G., Kopansky-Giles D., Åkesson K., March L. Reducing the global burden of musculoskeletal conditions. Bulletin of the World Health Organization. 2018; 96(5): 366-368. https://doi.org/10.2471/BLT.17.204891
  12. Cross M., Smith E., Hoy D., Nolte S., Ackerman I., Fransen M., Bridgett L., Williams S., Guillemin F., Hill C.L., Laslett L.L., Jones G., Cicuttini F., Osborne R., Vos T., Buchbinder R., Woolf A., March L. The global burden of hip and knee osteoarthritis: estimates from the global burden of disease 2010 study. Annals of the Rheumatic Diseases. 2014; 73(7): 1323-1330. https://doi.org/10.1136/annrheumdis-2013-204763
  13. Obesity and overweight. Key facts. World Health Organization, 2018. Available at: https://www.who.int/news-room/fact-sheets/detail/obesi-ty-and-overweight (accessed 06.12.2022).
  14. Perruccio A.V., Yip C., Badley E.M., Power J.D. Musculoskeletal Disorders: A Neglected Group at Public Health and Epidemiology Meetings? American Journal of Public Health. 2017; 107(10): 1584-1585. https://doi.org/10.2105/AJPH.2017.303990
  15. Postler A., Ramos A.L., Goronzy J., Gunther K.P., Lange T., Schmitt J., Zink A., Hoffmann F. Prevalence and treatment of hip and knee osteoarthritis in people aged 60 years or older in Germany: an analysis based on health insurance claims data. Clinical Interventions in Aging. 2018; (13): 2339-2349. https://doi.org/10.2147/CIA.S174741
  16. The Bone and Joint Decade. Global Alliance for Musculoskeletal Health. Key facts from The Global Burden of Disease 2012. Available at: http://bjdonline.org/?page_id=1574 (accessed 12.01.2022).
  17. Ulyanov V.Yu., Kalyuta T.Yu., Romakina N.A., Yurkovets A.A. Scientific report on the clinical study «Single-center, randomized, placebo-controlled, double-blind study to evaluate the effi- cacy, safety and tolerability of «B-Luron» dietary supplement in patients with osteoarthritis of the knee. Saratov. 2022: 68 p. (In Russ.).



Creative Commons License
The content is available under the Creative Commons Attribution 4.0 License.

©

Эта статья открытого доступа по лицензии CC BY 4.0. Издательство: ФГБУ «НМИЦ РК» Минздрава России.
This is an open article under the CC BY 4.0 license. Published by the National Medical Research Center for Rehabilitation and Balneology.

Aссоциация НАЭСКЛ