Issue №6-22, 2023

Original article

https://doi.org/10.38025/2078-1962-2023-22-6-78-90

Effectiveness of Sulfide Balneopeloidtherapy in Patients with Hypertension in Comorbid Combinations: Randomized Prospective Study

View article (Download PDF file)



Download XML file

1 ORCIDVladimir E. Vladimirskiy, 1 ORCIDEvgeny V. Vladimirskiy, 1 ORCIDRahma F.M. Hassaballa,1 ORCID Yulyia V. Karakulova,1 ORCID Natalya I. Gulyaeva

1Perm State Medical University named after Academician E.A. Wagner


ABSTRACT

INTRODUCTION. In the treatment of cardiovascular diseases, the use of hydrogen sulfide, which is a universal gas transmitter and performs many physiological functions in the body, is of interest.

AIM. To evaluate the effectiveness of sulfide balneopeloid therapy (SBPT), carried out at the Klyuchi resort (Perm region), in patients with arterial hypertension (AH), as well as their combinations with coronary heart disease (CHD), prediabetes and cerebrovascular disease (CVD) with chronic ischemia brain (CHM).

MATERIALS AND METHODS. A comparative randomized prospective study was conducted at the Klyuchi resort (Perm region), which studied the effectiveness of SBPT in patients with hypertension in various comorbid combinations. General inclusion criteria were the presence of hypertension and age from 40 to 70 years.

RESULTS. The results of a study of the effectiveness of different durations of SBPT in patients with hypertension showed that when a course of SBPT was carried out for 14 days, the hypotensive effect was less significant, while mid-term observation revealed that the hypotensive effect after a 21-day course of SBPT persisted for up to 6 months, and after 14-day course — 3 months. In patients with hypertension and prediabetes, complex therapy, including 14 days of SBPT, helps reduce the severity of clinical manifestations and improve quality of life; causes redistribution of fat deposits, improvement of blood pressure profile, aortic compliance, endothelial and neurogenic circuit of skin microcurrent regulation; reduces the serum concentration of vascular endothelial growth factor (VEGF), leptin, and also increases the serum concentration of transforming growth factor beta 1 (TGF-β1). When treating patients with hypertension and coronary artery disease using SBPT, an increase in the activity of the parasympathetic part of the nervous system, a lipid-correcting effect, improvement of endothelium-dependent vasodilation and exercise tolerance. The results of a study of patients with hypertension with CVD and MS showed that patients who received a course of SBRT had a significant improvement in cognitive functions.

DISCUSSION. The effects that develop during SBPT are associated with the polymodal effect of the H2S molecule on the main metabolic signaling pathways and regulatory mechanisms of the body’s hormonal-humoral systems, which leads to optimal regulation of micro- and macrohemodynamics, favorable changes in lipid metabolism, trophological status and trophic factors.

CONCLUSION. SBPT, carried out at the Klyuchi resort (Perm Region), is effective in patients with hypertension, including various comorbid combinations — hypertension and prediabetes, hypertension and ischemic heart disease, CCI.


KEYWORDS: sulfide balneopelotherapy, arterial hypertension, coronary heart disease, chronic cerebral ischemia, prediabetes, metabolic syndrome

Acknowledgments: The study had no sponsorship.

Conflict of interest:: The authors declare no apparent or potential conflicts of interest related to the publication of this article.

For citation: Khokhlova O.I., Vasilchenko E.M., Versh V.A., Denisova Ya.A. Coping Strategies and Burnout Among Medical and Social Workers Providing Services to People with Limited Mobility. Bulletin of Rehabilitation Medicine. 2023; 22(6):67-77. https://doi.org/10.38025/2078-1962-2023-22-6-67-77 (In Russ.).

Для корреспонденции: Vladimir E. Vladimirskiy, E-mail: vladimirskii_v@mail.ru, kaf.fakultter1@psma.ru



Список литературы:

  1. Баланова Ю.А., Шальнова С.А., Имаева А.Э. и др. Распространенность артериальной гипертонии, охват лечением и его эффективность в Российской Федерации (данные наблюдательного исследования ЭССЕ-РФ-2). Рациональная Фармакотерапия в Кардиологии. 2019; 15(4): 450–466. https://doi.org/10.20996/1819-6446-2019-15-4-450-466 [Balanova Yu.A., Shalnova S.A., Imaeva A.E. et al. Prevalence, Awareness, Treatment and Control of Hypertension in Russian Federation (Data of Observational ESSERF-2 Study). Rational Pharmacotherapy in Cardiology. 2019; 15(4): 450–466. https://doi.org/10.20996/1819-6446-2019-15-4-450-466 (In Russ.).]
  2. Бойцов С.А., Драпкина О.М., Шляхто Е.В. и др. Исследование ЭССЕ-РФ (Эпидемиология сердечно-сосудистых заболеваний и их факторов риска в регионах Российской Федерации). Десять лет спустя. Кардиоваскулярная терапия и профилактика. 2021; 20(5): 3007. https://doi.org/10.15829/1728-8800-2021-3007 [Boytsov S.A., Drapkina O.M., Shlyakhto E.V.et al. Epidemiology of Cardiovascular Diseases and their Risk Factors in Regions of Russian Federation (ESSE-RF) study. Ten years later. Cardiovascular Therapy and Prevention. 2021; 20(5): 3007. https://doi.org/10.15829/1728-8800-2021-3007 (In Russ.).]
  3. Дедов И.И., Шестакова М.В., Мельниченко Г.А. и др. Междисциплинарные клинические рекомендации «Лечение ожирения и коморбидных заболеваний». Ожирение и метаболизм. 2021; 18 (1): 5–99. https://doi.org/10.14341/omet12714 [Dedov I.I., Shestakova M.V., Melnichenko G.A. et al. Interdisciplinary Clinical Practice Guidelines “Management of Obesity and its Comorbidities”. Obesity and Metabolism. 2021; 18(1): 5–99. https://doi.org/10.14341/omet12714 (In Russ.).]
  4. Демидова Т.Ю., Кишкович Ю.С. Предиабет: современное состояние проблемы и возможности коррекции. РМЖ. Медицинское обозрение. 2019; 10(2): 60–67. [Demidova T.Yu., Kishkovich Yu.S. Prediabetes: the current state of the problem and the adjustment possibility. Russian Medical Inquiry. 2019; 10(I2): 60–67. (In Russ.).]
  5. Концевая А.В., Шальнова С.А., Драпкина О.М. Исследование ЭССЕ-РФ: эпидемиология и укрепление общественного здоровья. Кардиоваскулярная терапия и профилактика. 2021; 20(5): 2987. https://doi.org/10.15829/1728-8800-2021-2987 [Kontsevaya A.V., Shalnova S.A., Drapkina O.M. ESSE-RF study: epidemiology and public health promotion. Cardiovascular Therapy and Prevention. 2021; 20(5): 2987. https://doi.org/10.15829/1728-8800-2021-2987 (In Russ.).]
  6. Шестакова М.В., Драпкина О.М., Бакулин И.Г. Диагностика, лечение и диспансерное наблюдение пациентов с предиабетом в условиях первичной медико-санитарной помощи. 2021; 40 с. [Shestakova M.V., Drapkina O.M., Bakulin I.G. [Diagnosis, treatment and dispensary supervision of patients with pre-diabetes in the conditions of primary health care. 2021; p 40. (In Russ.).]
  7. Cosentino F., Grant P.J., Aboyans V. et al. 2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD The Task Force for diabetes, pre-diabetes, and cardiovascular diseases of the European Society of Cardiology (ESC) and the European Association for the Study of Diabetes (EASD). European Heart Journal. 2019; 41 (2): 255–323. https://doi.org/10.1093/eurheartj/ehz486
  8. Hostalek U. Global epidemiology of prediabetes — present and future perspectives. Clinical Diabetes and Endocrinology. 2019; 5: 5. https://doi.org/10.1186/s40842-019-0080-0
  9. Morer C., Roques C.F., Françon A. et al. The role of mineral elements and other chemical compounds used in balneology: data from double-blind randomized clinical trials. International Journal of Biometeorology. 2017; 61(12): 2159–2173. https://doi.org/10.1007/s00484-017-1421-2
  10. Cheleschi S., Gallo I., Tenti S. A comprehensive analysis to understand the mechanism of action of balneotherapy: why, how, and where they can be used? Evidence from in vitro studies performed on human and animal samples. International Journal of Biometeorology. 2020; 64(7): 1247–1261. https://doi.org/10.1007/s00484-020-01890-4
  11. Fernandez-Gonzalez M., Fernandez-Lao C., Martin-Martin L. et al. Therapeutic Benefits of Balneotherapy on Quality of Life of Patients with Rheumatoid Arthritis: A Systematic Review. International Journal of Environmental Research and Public Health 2021; 18(24): 13216. https://doi.org/10.3390/ijerph182413216
  12. Gálvez I., Torres-Piles S., Ortega-Rincón E. Balneotherapy, Immune System, and Stress Response: A Hormetic Strategy? International Journal of Molecular Sciences. 2018; 19(6): 1687. https://doi.org/10.3390/ijms19061687
  13. Carbajo J.M., Maraver F. Sulphurous Mineral Waters: New Applications for Health. Evidence- Based Complementary and Alternative Medicine. 2017; 4: 8034084. https://doi.org/10.1155/2017/8034084
  14. Liu J., Mesfin F.M., Hunter C.E. et al. Recent Development of the Molecular and Cellular Mechanisms of Hydrogen Sulfide Gasotransmitter. Antioxidants (Basel). 2022; 11(9): 1788. https://doi.org/10.3390/antiox11091788
  15. Costantino M., Conti V., Corbi G., Filippelli A. Hydropinotherapy with Sulphurous Mineral Water as Complementary Treatment to Improve Glucose Metabolism, Oxidative Status, and Quality of Life. Antioxidants (Basel). 2021; 10(11): 1773. https://doi.org/10.3390/antiox10111773
  16. Cuevasanta E., Benchoam D., Semelak J.A. et al. Possible molecular basis of the biochemical effects of cysteine-derived persulfides. Frontiers in Molecular Biosciences. 2022; 9: 975988. https://doi.org/10.3389/fmolb.2022.975988
  17. Hatami N., Büttner C., Bock F. Cystathionine β-synthase as novel endogenous regulator of lymphangiogenesis via modulating VEGF receptor 2 and 3. Communications Biology. 2022; 5(1): 950. https://doi.org/10.1038/s42003-022-03923-7
  18. Vladimirskiy V.E., Hassaballa F.M., Vladimirskiy E.V., Gulyaeva N.I. Experimental and Clinical Evidence of the Sulfide Balneotherapy Influence Efficacy on the Trophological and Regenerative Status: a Fundamental, Randomized Controlled Trial. Bulletin of Rehabilitation Medicine. 2022; 21(6): 134–144. https://doi.org/10.38025/2078-1962-2022-21-6-134-144
  19. Calabrese E.J., Mattson M.P., Dhawan G. et al. A potential strategic approach to the treatment of neurodegenerative disease. International Review of Neurobiology. 2020; 155: 271–301. https://doi.org/10.1016/bs.irn.2020.03.024
  20. Mao Y.G., Chen X., Zhang Y., Chen G. Hydrogen sulfide therapy: a narrative overview of current research and possible therapeutic implications in future. Medical Gas Research. 2020; 10(4): 185–188. https://doi.org/10.4103/2045-9912.304225
  21. Lv B., Chen S., Tang C. et al. Hydrogen sulfide and vascular regulation — An update. Journal of advanced Research. 2020; 27: 85–97. https://doi.org/10.1016/j.jare.2020.05.007
  22. Maccarone M.C., Masiero S. Can spa rehabilitative interventions play a role for patients suffering from neurodegenerative disorders at the early stages? A scoping review. International Journal of Biometeorology. 2022; 66(12): 2369–2377. https://doi.org/10.1007/s00484-022-02369-0
  23. Kolluru G.K., Shackelford R.E., Shen X. et al. Sulfide regulation of cardiovascular function in health and disease. Nature Reviews Cardiology. 2023; 20(2): 109–125. https://doi.org/10.1038/s41569-022-00741-6
  24. Li M., Mao J.C., Zhu Y.Z. Hydrogen Sulfide: a Novel Immunoinflammatory Regulator in Rheumatoid Arthritis. Advances in Hydrogen Sulfide Biology. 2021; 1315: 161–179. https://doi.org/10.1007/978-981-16-0991-6_7
  25. Kowalczyk-Bołtuć J., Wiórkowski K., Bełtowski J. Effect of Exogenous Hydrogen Sulfide and Polysulfide Donors on Insulin Sensitivity of the Adipose Tissue. Biomolecules. 2022; 12(5): 646. https://doi.org/10.3390/biom12050646



Creative Commons License
The content is available under the Creative Commons Attribution 4.0 License.

©

Эта статья открытого доступа по лицензии CC BY 4.0. Издательство: ФГБУ «НМИЦ РК» Минздрава России.
This is an open article under the CC BY 4.0 license. Published by the National Medical Research Center for Rehabilitation and Balneology.