Issue 23-5, 2024

Original article

https://doi.org/10.38025/2078-1962-2024-23-5-61-69

Bee Venom Phonophoresis on Mild to Moderate Localized Plaque Psoriasis on a Knee Joint: a Randomized Controlled Trial

View article (Download PDF file)



Download XML file

1 ORCIDHeba M. Elfeky , 2,* ORCIDAhmed M. Elfahl, 3 ORCIDMaha G. Ibrahim

1 Cairo University, Cairo, Egypt
2 Al-Zaytoonah University of Jordan, Amman, Jordan
3 Modern University for Technology and Information, Cairo, Egypt


ABSTRACT

INTRODUCTION. In psoriasis, plaque psoriasis is the most common kind. Patients may experience mild to severe symptoms, and while the sickness is not lethal, it is difficult to cure.
AIM. The purpose of this study is to evaluate the efficacy of bee venom phonophoresis in treating mild to moderate plaque psoriasis of the knee.
MATERIALS AND METHODS. Group A received bee venom phonophoresis in conjunction with conservative care, group B received bee venom topical application in conjunction with conservative care, and group C served as a control in a double-blind randomized controlled experiment including 96 patients with plaque psoriasis. Over the course of three months, every patient underwent a thorough evaluation that included blood tests to measure systemic inflammation (Neutrophil to lymphocyte ratio, C-reactive protein, and erythrocyte sedimentation rate), as well as PASI (Psoriasis Area and Severity Index) and Isokinetic knee proprioceptive.
RESULTS AND DISSCUSION. No statistically significant difference was found between the three groups at baseline measurement; however, a treatment effect was observed after 12 weeks of treatment (p = 0.001 and f-value = 50.718). In addition, both groups (A and B) showed a statistically significant interaction between pre- and post-treatment treatment and time; however, this interaction was much more pronounced and noticeable in group A.
CONCLUSION. Phonophoresis with bee venom improves proprioception in the knee joint and decreases N/L ratio, CRP, ESR, and PASI.
REGISTRATION: Clinicaltrials.gov identifier No. NCT06106230; registered 20.10.2023.


KEYWORDS: bee venom, plaque psoriasis, systemic inflammation, knee joint proprioception, phonophoresis

FUNDING: The authors declare no external funding in the conduct of the study.

CONFLICT OF INTEREST: The authors declare no apparent or potential conflicts of interest related to the publication of this article.

ДЛЯ ЦИТИРОВАНИЯ:

Elfeky H.M., Elfahl A.M., Ibrahim M.G. Bee Venom Phonophoresis on Mild to Moderate Localized Plaque Psoriasis on a Knee Joint: a Randomized Controlled Trial. Bulletin of Rehabilitation Medicine. 2024; 23(5):61-69. https://doi.org/10.38025/2078-1962-2024-23-5-61-69

ДЛЯ КОРРЕСПОНДЕНЦИИ:

Ahmed M. Elfahl, E-mail: a.ahmed@zuj.edu.jo, Ahmed.Abdel-Hady@pt.mti.edu.eg


References:

  1. Sunoqrot S., Niazi M., Al-Natour M.A., et al. Loading of Coal Tar in Polymeric Nanoparticles as a Potential Therapeutic Modality for Psoriasis. ACS Omega. 2022; 7(8): 7333–7340. https://doi.org/10.1021/acsomega.1c07267
  2. Raharja A., Mahil S.K., Barker J.N. Psoriasis: a brief overview. Clinical medicine (London, England). 2021; 21(3): 170–173. https://doi.org/10.7861/clinmed.2021-0257
  3. Bava, R., Castagna, F., Musella, V., et al. Therapeutic Use of Bee Venom and Potential Applications in Veterinary Medicine. Veterinary Sciences. 2023; 10(2): 119. https://doi.org/10.3390/vetsci10020119
  4. Lee J.D., Kim S.Y., Kim T.W., et al. Anti-inflammatory Effect of Bee Venom on Type II Collagen-Induced Arthritis. The American journal of Chinese medicine. 2004; 32(3): 361–367. https://doi.org/10.1142/S0192415X04002016
  5. Wehbe R., Frangieh J., Rima M., et al. Bee Venom: Overview of Main Compounds and Bioactivities for Therapeutic Interests. Molecules. 2019; 24(16): 2997. https://doi.org/10.3390/molecules24162997
  6. Bowen RA, Remaley AT. Interferences from blood collection tube components on clinical chemistry assays. Biochemia medica (Zagreb). 2014; 24(1): 31–44. https://doi.org/10.11613/BM.2014.006
  7. Sproston N.R., Ashworth J.J. Role of C-Reactive Protein at Sites of Inflammation and Infection. Frontiers in immunology. 2018; 9: 754. https://doi.org/10.3389/fimmu.2018.00754
  8. Higuchi M., Watanabe N. Determination of the erythrocyte sedimentation rate using the hematocrit-corrected aggregation index and mean corpuscular volume. J Clin Lab Anal. 2023; 37(6): e24877. https://doi.org/10.1002/jcla.24877
  9. Thaçi D., Strober B., Gordon K.B., et al. Deucravacitinib in Moderate to Severe Psoriasis: Clinical and Quality-of-Life Outcomes in a Phase 2 Trial. Dermatology and Therapy. 2022; 12(2): 495–510. https://doi.org/10.1007/s13555-021-00649-y
  10. Tuominen J., Leppänen M., Jarske H., et al. Test-Retest Reliability of Isokinetic Ankle, Knee and Hip Strength in Physically Active Adults Using Biodex System 4 Pro. Methods and protocols. 2023; 6(2): 26. https://doi.org/10.3390/mps6020026
  11. Barbaud A., Weinborn M., Garvey L.H., et al. Intradermal Tests with Drugs: An Approach to Standardization. Frontiers in medicine (Lausanne). 2020; 7: 156. https://doi.org/10.3389/fmed.2020.00156
  12. Othman E.M., Hamada H.A., Mohamed G.I., et al. Clinical and histopathological responses to bee venom phonophoresis in treating venous and diabetic ulcers: a single-masked randomized controlled trial. Frontiers in medicine (Lausanne). 2023; 10: 1085544. https://doi.org/10.3389/fmed.2023.1085544
  13. Şenel E., Kuyucu M., Süslü I. Honey and bee venom in dermatology: A novel possible alternative or complimentary therapy for psoriasis vulgaris. Ancient science of life. 2014; 33(3): 192–193. https://doi.org/10.4103/0257-7941.144626
  14. Watanabe A.S., Fonseca L.A., Galvão C.E. Specific immunotherapy using Hymenoptera venom: Systematic review. São Paulo medical journal = Revista paulista de medicina. 2010; 128(1): 30–37. https://doi.org/10.1590/s1516-31802010000100007
  15. Chen J., Lariviere W.R. The nociceptive and anti-nociceptive effects of bee venom injection and therapy: A double-edged sword. Progress in Neurobiology 2010; 92(2): 151–183. https://doi.org/10.1016/j.pneurobio.2010.06.006
  16. Othman E.M., Abdelbasset W.K., Elsayed S.H., et al. Effect of ultrasound-enhanced bee venom on selected post inguinal hernioplasty complications: a single-masked randomized controlled trial. European review for medical and pharmacological sciences. 2023; 27(2): 483–492. https://doi.org/10.26355/eurrev_202301_31048
  17. Hegazi A.G., Raboh F.A.A., Ramzy N.E., et al. Bee venom and propolis as a new treatment modality in patients with localized plaque psoriases. International Research Journal of Medicine and Medical Sciences. 2013; 1: 27–33.
  18. Eltaher S., Mohammed G.F., Younes S., Elakhras A. Efficacy of the apitherapy in the treatment of recalcitrant localized plaque psoriasis and evaluation of tumor necrosis factor-alpha (TNF-alpha) serum level: A double-blind, randomized clinical trial. The Journal of dermatological treatmen. 2015; 26: 335–339. https://doi.org/10.3109/09546634.2014.990411
  19. Hozzein W.N., Badr G., Badr B.M., et al. Bee venom improves diabetic wound healing by protecting functional macrophages from apoptosis and enhancing Nrf2, Ang-1 and Tie-2 signaling. Molecular immunology. 2018; 103: 322–335. https://doi.org/10.1016/j.molimm.2018.10.016
  20. Park H.J., Lee S.H., Son D.J., et al. Antiarthritic effect of bee venom: Inhibition of inflammation mediator generation by suppression of NF-κB through interaction with the p50 subunit. Arthritis and rheumatism. 2004; 50: 11. https://doi.org/10.1002/art.20626
  21. Jeong J.K., Moon M.H., Bae B.C., et al. Bee venom phospholipase A2 prevents prion peptide induced-cell death in neuronal cells. International Journal of Molecular Medicine, 2011; 28(5): 867–873. https://doi.org/10.3892/ijmm.2011.730
  22. Asafova N.N., Orlov B.N., Kozin R.B. Physiologically active bee products (in Russian). Y.A. Nikolaev Nijnij Novgorod. 2001: 360 p.
  23. Tsai L.C., Lin Y.W., Hsieh C.L. Effects of bee ven om injections at acupoints on neurologic dysfunction induced by thoracolumbar intervertebral disc disorders in canines: a Randomized, Controlled Prospective Study. BioMed research international. 2015; 2015: 363801. https://doi.org/10.1155/2015/363801
  24. Yasin M.M., Elhosary E.A., Hamada H.A., et al. Effect of bee venom phonophoresis in obese polycystic ovarian women: A Single Blind Randomized Controlled Trial. Journal of Applied Pharmaceutical Science. 2018; 8: 159–164. http://dx.doi.org/10.7324/JAPS.2018.8124
  25. Park H.J., Chang H.J., Kim T.G., et al. Alteration of Thi and Thi 7 Inflammatory Cytokines in the Skin Lesions after Psoriasis Treatment. Korean Journal of Dermatology, 2022; 60(7): 409–413.
  26. Dadar M., Shahali Y., Chakraborty S., et al. Antiinflammatory peptides: current knowledge and promising prospects. Inflammation Research. 2019; 68: 125–145. https://doi.org/10.1007/s00011-018-1208-x
  27. Jang S., Kim K.H. Clinical Effectiveness and Adverse Events of Bee Venom Therapy: A Systematic Review of Randomized Controlled Trials. Toxins (Basel). 2020; 12(9): 558. https://doi.org/10.3390/toxins12090558
  28. Nam K.W., Je K.H., Lee J.H., et al. Inhibition of Cox-2 activity and pro-inflammatory cytokines (TNF-α and IL-1β) production by water-soluble sub-fractionated parts from bee (Apis mellifera) venom. Archives of pharmacal research. 2003; 26(5): 383. https://doi.org/10.1007/BF02976695
  29. Altan L.A., Aksoy M.K., Öztürk E.K. Efficacy of diclofenac & thiocolchioside gel phonophoresis comparison with ultrasound therapy on acute low back pain; a prospective, double-blind, randomized clinical study. Ultrasonics 2019; 91: 201–205. https://doi.org/10.1016/j.ultras.2018.08.008
  30. Kołaczek A., Skorupa D., Antczak-Marczak M., et al. Safety and efficacy of venom immunotherapy: a real-life study. Postepy Derma tol Alergol 2017; 34: 159–167. https://doi.org/10.5114/ada.2017.67082
  31. Shim W.H., Park H.J., Kim H.S., et al. Mybacterium chelonae infection occurring at the site of bee sting therapy. Korean Journal of Dermatology. 2011; 49(4): 374–378.



Creative Commons License
The content is available under the Creative Commons Attribution 4.0 License.

©


This is an open article under the CC BY 4.0 license. Published by the National Medical Research Center for Rehabilitation and Balneology.