Issue 23-6, 2024

Review

https://doi.org/10.38025/2078-1962-2024-23-6-90-99

A Comparative Review of Traditional and Prospective Methods for Vitiligo Treatment

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1 ORCIDOlga Yu. Olisova,1,* ORCID Lyailya N. Kayumova,2 ORCID Petr S. Eremin,2 ORCID Ilmira R. Gilmutdinova,1 ORCIDVladimir B. Pinegin, 1 ORCID Kira Yu. Kryuchkova, 1 ORCIDKonstantin M. Lomonosov

1 I.M. Sechenov First Moscow State Medical University, Moscow, Russia
2 National Medical Research Center for Rehabilitation and Balneology, Moscow, Russia


ABSTRACT

INTRODUCTION. Vitiligo is an acquired skin disease characterized by loss of pigmentation with the destruction of epidermal melanocytes. The etiology and pathogenesis of this disease are still poorly understood. The course of vitiligo affects the patient's quality of life, his psychological state and self-esteem. In this regard, there is a need to develop new and promising methods aimed at stimulating and modulating the reparative processes of damaged tissues.
AIM. To review the scientific literature on traditional therapy and new approaches to the treatment of vitiligo.
MATERIALS AND METHODS. The literature review was conducted using the RINTS, PubMed and ScienceDirect databases. Query dates — March–July 2024, query depth — 1964–2024.
MAIN CONTENT OF THE REVIEW. Conservative treatment methods are aimed at inhibiting the pathological process, preventing the appearance of new spots and reducing the cosmetic defect. Thus, patients are prescribed topical and systemic glucocorticosteroids, calcineurin inhibitors, immunosuppressants, phototherapy both in monotherapy and in combination. In recent years, technologies based on transplantation of autologous suspension of regenerative skin cells have been considered the most promising.
CONCLUSION. Innovative methods of regenerative medicine are a good alternative to traditional treatments for patients with stable vitiligo, especially for those who do not respond to standard drug therapy.

KEYWORDS: vitiligo, split-thickness skin grafts, miniature punch grafting, hair follicular transplantation, epidermal cell suspension, transplantation of autologous melanocytes, epithelial grafting

FUNDING: The authors declare no external funding in the conduct of the study.

CONFLICT OF INTEREST: The authors declare no apparent or potential conflicts of interest related to the publication of this article.

FOR CITATION:

Olisova O.Yu., Kayumova L.N., Eremin P.S., Gilmutdinova I.R., Kryuchkova K.Yu., Pinegin V.B., Lomonosov K.M. A Comparative Review of Traditional and Prospective Methods for Vitiligo Treatment. Bulletin of Rehabilitation Medicine. 2024; 23(6):90-99. https://doi.org/10.38025/2078-1962-2024-23-6-90-99 (In Russ.).

FOR CORRESPONDENCE:

Lyailya N. Kayumova, kayumova_l_n@staff.sechenov.ru


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This is an open article under the CC BY 4.0 license. Published by the National Medical Research Center for Rehabilitation and Balneology.