Issue №5-93, 2019

The therapy of the psychosomatic and adaptive diseases, and toxicopathy by small doses of xenon in patients with postovariectomy syndrome after surgical treatment of the cervical cancer

¹ Popova N.N., ¹ Shikhlyarova A.I., ¹ Men’shenina A.P., ¹ Tikhonova S.N., ¹ Arapova Yu.Yu., ¹ Protasova T.P., ¹ Skopintsev A.M.

¹ Rostov Research Institute of Oncology, Rostov-on-Don, Russia

ABSTRACT

The aim of the current study was testing new dose algorithm of activation xenon therapy for therapy postovariectomysyndrome in women of reproductive age with cervical cancer at the early postoperative period. The 28 patients (aged39.4±3.7 yr.) with gynecological cancer who underwent surgery in the amount of extended panhysterectomy about cervicalcancer, who developed signs of postovariectomy syndrome in the immediate postoperative period, participated in study.The xenon therapy was used additionally to the basic therapy on the fourth day after surgery. The xenon therapy was basedon the programmable exponential algorithm developed for small subnarcotic doses of xenon, which included gradually increasingthe xenon content by 2–4% with a reciprocal decrease in exposure time. The toxicopathy, adaptive and psychoemotionalstates were determined before surgery, at the third day after surgery and at the termination of the therapy. It is foundthat xenon therapy at the early postoperative period induced acute stress as well as allowed to prevent the pathologicalaccumulation of products of an incomplete metabolism and endotoxins. This was evidenced by the indicators of the bloodleukocyte shift index, the leukocyte intoxication index, the nuclear index and the Shagin leukocyte index. The decreasein the frequency antistress, hormone-modulating, sedative and of the main symptoms of the postovariectomy syndrome,improvement of psycho-emotional state, expressed in a decrease in anxiety, fatigue, depression, normalization of sleepand appetite, were received. These data were fully corresponded to the nature of the adaptation reaction of the anti-stresstype. So, the new dose algorithm of activation xenon therapy is more reasonable approach in the functional rehabilitationand rehabilitation therapy of early manifestations of the postovariectomy syndrome in the women of reproductive age withcervical cancer at the early postoperative period

KEYWORDS: cervical cancer, postovariectomy syndrome, adaptive state, toxicopathy, psychoemotional state, xenon therapy, functional rehabilitation.

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This is an open article under the CC BY 4.0 license. Published by the National Medical Research Center for Rehabilitation and Balneology.