Issue №5-20, 2021

Original article

https://doi.org/10.38025/2078-1962-2021-20-5-92-98

The Effect of the Vitamin D Receptor on Bone Metabolism Disorders in Premature Infants Born Using In Vitro Fertilization

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1 ORCIDNatalia A. Druzhinina, 1,2 ORCIDDinara R. Merzlyakova, 1 ORCIDNaila R. Hafizova, 1 ORCIDValentina Yu. Gorbunova, 1 ORCIDLilia R. Imaeva, 1 ORCIDGulnaz A. Vahitova, 1,3 ORCIDLilia R. Khalikova

1 Bashkir State Medical University, Ufa, Russian Federation
2 Republican Children’s Clinical Hospital, Ufa, Russian Federation
3 Republican Clinical Perinatal Center, Ufa, Russian Federation


ABSTRACT

AIM. To study the effect of the vitamin D receptor on bone metabolism disorders in premature infants born using in vitro fertilization (IVF).

MATERIAL AND METHODS. A study was conducted on 189 premature infants, divided into 2 groups. The first group is premature babies born using the IVF method. The second group – children were born naturally. The VDR receptor gene was analyzed depending on the observation groups.

RESULTS. It was found that in children born with IVF, the signs of osteopenia were more pronounced. Genetic studies have shown that the frequency of mutant allele *B and homozygous mutant genotype B/B of the VDR gene is more common in premature babies born with IVF. Mutant homozygous genotype B/B occurs in the main group of children with a frequency of 35%, which is significantly higher than in the control group of children (17%). Changes in bone metabolism are one of the important causes of musculoskeletal system disorders, which is closely associated with the molecular genetic polymorphism of the VDR gene.

CONCLUSION. The studies conducted led to the following conclusion: the frequency of the mutant allele *B and homozygous for the mutant allele genotype B/B, occurs more often in premature babies born using IVF. The frequency of the *B allele in the group of premature babies born using IVF is 50%, which is higher than in the group of premature babies born naturally (40%). However, the identified genetic differences are not associated with the IVF procedure. These are combinations of gene alleles inherited from the parents. Knowledge of hereditary risk factors for low vitamin D3 levels can be of great practical importance for predicting bone metabolism disorders in premature infants.


KEYWORDS: vitamin D receptor, VDR gene, premature babies, IVF

Acknowledgments: The study had no sponsorship

Conflict of interest:: The authors declare no apparent or potential conflicts of interest related to the publication of this article.

For citation: Druzhinina N.A., Merzlyakova D.R., Hafizova N.R., Gorbunova V.Yu., Imaeva L.R., Vahitova G.A., Khalikova L.R. The Effect of the Vitamin D Receptor on Bone Metabolism Disorders in Premature Infants Born Using In Vitro Fertilization. Bulletin of Rehabilitation Medicine. 2021; 20 (5): 92-98. https://doi.org/10.38025/2078-1962-2021-20-5-92-98

For correspondence: Dinara R. Merzlyakova, e-mail: dinara-merzlyakova@mail.ru



References:

  1. Engelman C.D., Meyers K.J., Iyengar S.K., Liu Z., Karki C.K., Igo Jr. R.P., Truitt B., Robinson J., Sarto G.E., Wallace R., Blodi B.A., Klein M.L., Tinker L., LeBlanc E.S., Jackson R.D, Song Y., Manson E. JoAnn, Mares J.A., Millen A.E. Vitamin D intake and season modify the effects of the GC and CYP2R1 genes on 25 hydroxyvitamin D concentrations. The Journal of Nutrition. 2013; 143(1): 17-26. https://doi.org/10.3945/jn.112.169482
  2. Nissen J., Rasmussen L.B., Ravn-Haren G., Andersen E.W., Hansen B., Andersen R., Mejborn H., Madsen K.H., Vogel U. Common variants in CYP2R1 and GC genes predict vitamin D concentrations in healthy Danish children and adults. Plos One. 2014; 9(2): e89907. https://doi.org/10.1371/journal.pone.0089907
  3. Boychuk A.V., Budnik T.A., Boyarchuk O.R. Obespechennost beremennyh vitaminom D I eyo vliyanie na antropometricheskie pokasately novorogdennogo [Maternal vitamin D status and association with neonatal anthropometric measures]. Problems of Nutrition. 2020; 89(5): 80-88. https://doi.org/10.24411/0042-8833-2020-10068 (In Russ.).
  4. Ekimov A.N., Alexandrova N.V., Shubina E.S., Ritcher O.V., Goltsov A.Yu., Nazarenko T.A. Genotipirovanie embrionov s pomochu fragmentnogo str- analiza posle provedenia polnogenomnoy amplificacii [Embryo genotyping using fragment str analysis after genome-wide amplification]. Obstetrics and Gynecology. 2021; (1): 126-132. https://doi.org/10.18565/aig.2021.1.126-132 (In Russ.).
  5. Omarova N.H., Soltakhanov E.M., Omarova P.A. Geneticheskie factory defisita vitamina D i ih klinichescoe snachenie [Genetic factors of vitamin D3 deficiency and their clinical significance]. Environmental Medicine. 2019; 2(1): 72-78. https://doi.org/10.34662/EM.2019.2.1.72-78 (In Russ.).
  6. Povorozniuk V.V., Pludovski P., Balatskaia N.I., Muts V.Ya. Defitsit i nedostatochnost vitamina D epidemiologia, diagnostika, profilaktika i lechenie [Vitamin D deficiency and insufficiency: epidemiology, diagnosis, prevention and treatment]. Kiev. 2015: 262 p. (In Russ.).
  7. Zakharova I.N., Klimov L.Ya., Yagupova A.V., Kuryaninova V.A., Dolbnya S.V., Tsutsayeva A.N., Dyatlova A.A., Verisokina N.E., Alkhimidi A.A., Minasyan A.K.Vnedrenie nacionalnoy programmy po profilaktike I correkcii gipovitaminoza D u detey: pervye resultaty v gruppe rannego vosrasta [Introduction of the national program for the prevention and correction of hypovitaminosis D in children: the first results in the early age group]. Journal «Pediatria». 2021; (100): 67-74. https://doi.org/10.24110/0031-403X-2021-100-1-67-74 (In Russ.).
  8. Kostrova G.N., Malyavskaya S.I., Lebedev A.V. Nedostatochnost Vitamina D i parametry uglevodnogo obmena u detey i podrostcov s ogireniem [Vitamin D deficiency and obese adolescents]. Problems of Nutrition. 2021; (90): 57-64. https://doi.org/10.33029/0042-8833-2021-90-1-57-64 (In Russ.).
  9. Savlevich E.L., Gorbunov S.A., Felshin D.I., Gerasimov A.N., Molodnitskaya A.Yu. Analis shem diagnostiki i lecheniy astryh vospolitelnyh sabolevani verhnih dyhatelnyh putey po dannym poliklinniki upravleniy delamy Presidenta RF [Analysis of diagnostic and treatment schemes for acute inflammatory diseases of the upper respiratory tract according to the data of polyclinics of the Presidential Administration of the Russian Federation].
  10. Journal «Pediatria». 2021; (100): 136-14. https://doi.org/10.24110/0031-403X-2021-100-1-136-144 (In Russ.).
  11. Harrison S.R., Li D., Jeffery L.E., Raza K., Hewison M. Vitamin D, Autoimmune Disease and Rheumatoid Arthritis. Calcified Tissue International. 2020; (106): 58-75. https://doi.org/10.1007/s00223-019-00577-2
  12. Jiang W., Wu D.B., Xiao G.B., Ding B., Chen E.Q. An epidemiology survey of vitamin D deficiency and its influencing factors. Medicina Clinica (Barcelona). 2020; (154): 7-12. https://doi.org/10.1016/j.medcli.2019.03.019
  13. Lv L., Tan X., Peng X., Bai R., Xiao Q., Zou T., Tan J., Zhang H., Wang C. The relationships of vitamin D, vitamin D receptor gene polymorphisms, and vitamin D supplementation with Parkinson’s disease. Translational Neurodegeneration. 2020; (9): 34 p. https://doi.org/10.1186/s40035-020-00213-2
  14. Bogdanova G.S., Zaidieva Z.S., Magometkhanova D.M., Zayakin V.A. Nazarova E.A. Nevynashivanie beremennosty: obshiy vsglyad na problemu [Miscarriage of pregnancy: a general view of the problem]. Medical Council. 2012; (3): 67-71 (In Russ.).
  15. Zakharova I.N., Maltsev S.V., Borovik T.E., Yatsyk G.V., Malyavskaya S.I., Vakhlova I.V., Shumatova T.A., Romantsova E.B., Romanyuk F.P., Klimov L.Ya., Pirozhkova N.I., Kolesnikova S.M., Kuryaninova V.A., Tvorogova T.M, Vasilyeva S.V., Mozzhukhina M.V., Evseeva E.A. Resultaty mnogocentrovogo kogortnogo issledovania «Rodnichok» po isucheniu nedostatochnosty vitamina D u detey rannego vosrasta v Rossii (2013-2014 gg.). [Vitamin D Insufficiency in Children of Tender Years in Russia: the Results of a Multi-Centre Cohort Study «Rodnichok» (2013-2014)]. Current Pediatrics. 2014; 13(6): 30-34. https://doi.org/10.15690/vsp.v13i6.1198 (In Russ.).
  16. Zakharova I.N., Maltsev S.V., Borovik T.E., Yatsyk G.V., Malyavskaya S.I., Vakhlova I.V., Shumatova T.A., Romantsova E.B., Romanyuk F.P., Klimov L.Ya., Elkina T.N., Pirozhkova N.I., Kolesnikova S.M., Kuryaninova V.A., Vasilyeva S.V., Mozzhukhina M.V., Evseeva E.A. Nedostatochnost vitamina D u detey rannego vosrasta v Rossii (resultaty mnogocentrovogo issledovania: sima 2013-2014 gg.) [Vitamin D deficiency in young children in Russia (results of a multicenter study: winter 2013-2014)]. Journal «Pediatria». 2014; 93(2): 75-80 (In Russ.).
  17. Garland C.F., Kim J.J., Mohr S.B., Gorham E.D., Grant W.B., Giovannucci E.L., Baggerly L., Ramsdell J.W., Zeng K., Heaney R.P. Meta-analysis of all – cause mortality according to serum 25-Hydroxyvitamin D. American Journal of Public Health. 2014; 104(8): 43-50. Hossein-nezhad A., Spira A., Holick M.F. Influence of vitamin D status and vitamin D3 supplementation on genome wide expression of white blood cells: a randomized double-blind clinical trial. Plos One. 2013; (8): 3 p. https://doi.org/10.1371/journal.pone.0058725
  18. Mohammad H.M., Mousazadeh S., Maleknia M., Takhshid M. Association of vitamin D deficiency with vitamin D binding protein (DBP) and CYP2R1 polymorphisms in Iranian population. Meta Gene. 2021; 27(4): 100824. https://doi.org/10.1016/j.mgene.2020.100824
  19. Hiraki L.T., Major J.M., Chen C., Cornelis M.C., Hunter D.J., Rimm E.B., Simon K.C., Weinstein S.J., Purdue M.P., Yu K., Albanes D., Kraft P. Exploring the genetic architecture of circulating 25 – hydroxyvitamin D. Genetic Epidemiology. 2013; 37(1): 92-98. https://doi.org/10.1002/gepi.21694
  20. Fleet J.C., Schoch R.D. Molecular mechanisms for regulation of intestinal calcium absorption by vitamin D and other factors. Critical Reviews in Clinical Laboratory Sciences. 2010; 47(4): 181-195. https://doi.org/10.3109/10408363.2010.536429
  21. Kutikhin A.G., Yuzhalin A.E., Ponasenko A.V. Sovremennoe tendencii statistichescoy obrabotki dannyh i predstavlenia resultatov v kandidatnyh genetico- epidemiologicheskih isledovaniyah [Modern trends in statistical data processing and presentation of results in candidate genetic and epidemiological studies]. Fundamental and Clinical Medicine. 2017; 2(2): 77-82 https://doi.org/10.23946/2500-0764-2017-2-2-77-82 (In Russ.).



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