Issue 6-20, 2021

Original article

https://doi.org/10.38025/2078-1962-2021-20-6-103-110

Laboratory Parameters of Bone Metabolism in Premature Infants and Children Born Using In Vitro Fertilization

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1 ORCIDNatalya A. Druzhinina, 1 ORCIDDinara R. Merzlyakova, 1 ORCIDGulnaz A. Vakhitova, 1 ORCIDZilia А. Shangareeva, 1 ORCIDAliya R. Khabibullina, 1 ORCIDNaila R. Hafizova, 1 ORCIDSania V. Shagarova

1 Bashkir State Medical University, Ufa, Russian Federation


ABSTRACT

AIM. To study the indicators of bone metabolism in premature babies born naturally and children born with IVF.

MATERIAL AND METHODS. The premature babies’ study was conducted, they were divided into 4 groups: depending on the method of birth and weight: 1st-children born with IVF, with very low weight; the second group – similar to the first, but children with extremely low weight; the third – children with very low weight, born naturally, with ; the fourth – similar to the 3rd, but with extremely low weight. The level of calcium, parathyroid hormone, calcitonin and C-terminal telopeptides of type I collagen was determined.

RESULTS AND DISCUSSION. Diagnosis of vitamin D deficiency is possible only by measuring certain biochemical parameters, primarily the levels of its metabolites in the blood. Clinical symptoms of vitamin D deficiency in the form of rickets, osteomalacia, osteoporosis and extra-skeletal manifestations as a result of this vitamin deficiency occur over a long period of time. The most informative indicator of the body’s vitamin D supply is the content of calcidiol [25 (OH)D] in both serum and blood plasma. Vitamin D deficiency was detected in more than half (67.7±4.8%) of premature newborns in the first year of life. It seemed that in premature babies born in different ways, vitamin D deficiency was noted in 8 %, insufficiency – in 67.7 %, and the normal content in 27.5 %. In children at an early age, there is a violation of bone metabolism (an increase in the level of calcium, parathyroid hormone, calcitonin, on the one hand, and a decrease in the C-terminal telopeptides of type I collagen, on the other). These changes were associated with the weight of children, while aggressive disorders were noted in children with extremely low weight. In premature infants (with a body weight of less than 1500 g), monitoring of the level of vitamin D in the blood and C-terminal telopeptides of type 1 collagen should be recommended.

CONCLUSION. Bone modeling has a great advantage due to the analysis of the blood serum biomarkers levels in premature infants, it enables to establish the features of osteogenesis.


KEYWORDS: IVF, premature infants, vitamin D, bone metabolism

FUNDING: The study had no sponsorship

CONFLICT OF INTEREST: The authors declare no apparent or potential conflicts of interest related to the publication of this article

FOR CITATION: Druzhinina N.A., Merzlyakova D.R., Vakhitova G.A., Shangareeva Z. А., Khabibullina A.R., Khafizova N.R., Shagarova S.V. Laboratory Parameters of Bone Metabolism in Premature Infants and Children Born Using In Vitro Fertilization. Bulletin of Rehabilitation Medicine. 2021; 20 (6): 103-110. https://doi.org/10.38025/2078-1962-2021-20-6-103-110

FOR CORRESPONDENCE:

Dinara R. Merzlyakova, e-mail: Dinara-merzlykova@mail.ru


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This is an open article under the CC BY 4.0 license. Published by the National Medical Research Center for Rehabilitation and Balneology.