Issue №3-21, 2022

Efficacy Evaluation for Application of Pharmacological Complexes with Indications on Fatigue Prevention

¹ Evgeniy. V. Goloborodko

¹ Burnazyan Federal Medical Biophysical Center, Moscow, Russian Federation

ABSTRACT

An urgent task today is the formation of scientific approaches to the creation of a system to assess the effectiveness of medicaltechnologies in sports medicine, taking into account the increased requirements not only in assessing their safety, but also withthe mandatory analysis of their impact on the parameters of functional readiness of the athlete. We conducted the study usinga comprehensive methodological approach developed in terms of the possibility of its application in case of mono-factorial exposure(means of pharmacological support).Aim. To determine the effectiveness of pharmacological agent’s complexes indicated for use in the prevention of fatigue by their effecton physical performance and psycho-emotional state of persons professionally engaged in sports.Material and methods. We performed a retrospective analysis of 30 athletes involved in skiing sports (biathlon, cross-country skiingand cross-country skiing) and evaluated the efficacy of two combinations of pharmacological agents not included in the WADA bannedlist, indicated for the prevention of fatigue, compared with placebo. Functional state of the athletes was estimated on the 7th and 15thdays according to the parameters of endurance testing on the “Norwegian” protocol “until failure”, 5 loading steps, psychoemotionalstate (hardware-software complex “Diamed-MBS”, psychological status (Lusher test, WAM, Mini-Mult) on the 7th and 15th days. Weanalyzed the dynamics of general and biochemical blood tests, general urinalysis.Results and discussion. Load time before failure, the main indicator characterizing the success of the athlete’s professional activity, didnot differ in all three groups when testing the background values, on the 7th and 15th days of the study, but consistently increased fromthe beginning to the end of the experiment. On the 15th day, 15 the time of specific load “to failure” in all three groups differed fromthe corresponding background values (p <0.05) due to the training effect. Application of the evaluated drugs had no effect on the levelof IPC index in all three groups, but it tended to increase by the end of the experiment due to the trained athletes. The use of the drugshad no effect on the psycho-emotional and psychological state in all groups under study and at all testing points.Conclusion. Evaluation of the sports medicine technologies effectiveness should be carried out taking into account the requirementsfor their impact on the functional readiness of athletes, determining the success of professional activity. The studies have revealed noinfluence of the course application of the schemes of pharmacological agents of GCS and GCM against the background of the standardtraining program and periodic submaximal physical activity on the functional capabilities of the athletes’ organisms. The possibility ofusing the developed methodological approach to evaluate the effectiveness of sports medicine technologies based on monofactorialeffects is shown, using the example of approved pharmacological agents indicated for reducing fatigue.

KEYWORDS: physical performance, specific stress testing, psycho-emotional state, performance evaluation, athletes

For citation: Goloborodko E.V. Efficacy Evaluation for Application of Pharmacological Complexes with Indications on Fatigue Prevention. Bulletin of Rehabilitation Medicine. 2022; 21 (3): 181-188. https://doi.org/10.38025/2078-1962-2022-21-3-181-188

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