Issue №5-21, 2022
The Effect of Lifestyle Correction Based on Body Composition Intervention on Clinical Efficacy: a Prospective Comparative Randomized Study of Polycystic Ovary Syndrome Patients
1 Zhang Xin-Yuan, 1 Fu Ling-Ling, 1 Song Ke, 1 He Ting-Ting, 1 Yang Jing, 1 Chang Jun, 1 Su Li Meng Wu Jun, 1 Li Jie, 1 Yao Lei, 1 Zhang Yan, 1 Liu Jiang-Ling
1 Urumqi First People's Hospital, Xinjiang, China
ABSTRACT
AIM. To study the clinical effect of body composition-based lifestyle intervention in patients with polycystic ovary syndrome (PCOS).
MATERIAL AND METHODS. In the period of November, 2020 – July, 2021, 91 patients diagnosed with PCOS in the First People's Hospital of Urumqi were prospectively selected and divided into a control group (46 cases) and an experimental group (45 cases) according to random number method. The patients in the control group were treated with Drospirenone and Ethinylestradiol tablets (II), while the patients in the experimental group were treated with Drospirenone and Ethinylestradiol tablets (II) and lifestyle adjustment based on body composition. The changes of the indices before and after 3 months of treatment were compared between the two groups.
RESULTS. The indices of PCOS patients in the two groups after treatment (except 1 basal metabolic rate and muscle weight, 2. FSH and 3. HDL) were decreased, and the decrease in the experimental group was more significant (P < 0.05). Patients in the experimental group had significantly increased spontaneous ovulation and pregnancy rate / Conducive to ovulation and pregnancy.
CONCLUSION. In PCOS patients, the combination of Drospirenone and Ethinylestradiol tablets (II) and lifestyle intervention based on human body components can improve reproductive hormone, glucose metabolism and insulin resistance more effectively, which is beneficial to spontaneous ovulation and pregnancy, and reduce the weight of patients.
KEYWORDS: body composition, life style, polycystic ovary syndrome, Anti-Mullerian hormone, Insulin resistance
For citation: Zhang X.Y., Fu L.L., Song K., He T.T., Yang J., Chang J., Su L.M.W.J., Li J., Yao L., Zhang Y., Liu J.L. The Effect of Lifestyle Correction Based on Body Composition Intervention on Clinical Efficacy: a Prospective Comparative Randomized Study of Polycystic Ovary Syndrome Patients. Bulletin of Rehabilitation Medicine. 2022; 21 (5): 42-49. https://doi.org/10.38025/2078-1962-2022-21-5-42-49
References:
1. Joham Anju E., Norman Robert J., Stener-Victorin Elisabet. et al. Polycystic ovary syndrome. The Lancet Diabetes & Endocrinology. 2022; 9(10): 668-680. https://doi.org/10.1016/S2213-8587(22)00163-2
2. Shan Hongying, Luo Renxin, Guo Xuanying. et al. Abnormal Endometrial Receptivity and Oxidative Stress in Polycystic Ovary Syndrome. Frontiers in Pharmacology. 2022; (13): 904942. https://doi.org/10.3389/fphar.2022.904942
3. Gu Yuanyuan., Zhou Guannan., Zhou Fangyue. et al. (2022). Life Modifications and PCOS: Old Story but New Tales. Frontiers in Endocrinology. 2022; (13): 808898.https://doi.org/10.3389/fendo.2022.808898
4. Katulski Krzysztof, Czyzyk Adam, Podfigurna-Stopa Agnieszka, Genazzani Andrea R, Meczekalski Blazej. Pregnancy complications in polycystic ovary syndrome patients. Gynecological Endocrinology. 2015; 31(2): 87-91. https://doi.org/10.3109/09513590.2014.974535
5. Li Wencheng, Chen Lijun. Effects of nutritional therapy management on body composition, endocrine metabolism and reproductive function in patients with PCOS. Journal of Baotou Medical College. 2018; 34(02). https://doi.org/10.16833/j.cnki.jbmc.2018.02.027
6. Mitra Subarna, Saharia Gautom,and Jena Saubhagya. Correlation between serum AMH levels and cardiometabolic indices in PCOS women. Indian Journal of Endocrinology and Metabolism. 2021; 6(25): 545-550. https://doi.org/10.4103/IJEM.IJEM_421_21
7. Zhang Pingping, Zhang Xiaoping. Effects of nutritional therapy management on body composition, endocrine metabolism and reproductive function in patients with PCOS. Journal of Baotou Medical College. 2018; 34(02). https://doi.org/10.16833/j.cnki.jbmc.2018.02.027
8. Budi Wiweko, Mila Maidarti, M. Dwi Priangga, Nadia Shafira, Darrell Fernando, Kanadi Sumapraja, Muharam Natadisastra, Andon Hestiantoro. Anti-mullerian hormone as a diagnostic and prognostic tool for PCOS patients. Journal of Assisted Reproduction and Genetics. 2014:1311-1316. https://doi.org/10.1007/s10815-014-0300-6
9. Recommendations of international evidence-based guidelines for the assessment and management of polycystic ovary syndrome. Chinese Journal of Reproductive and Contraception. 2019: 259-268.
10. Teede Helena J., Marie L. Misso, Michael F. Costello, Anuja Dokras, Joop Laven, Lisa Moran, Terhi Piltonen, Robert J. Norman. Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome. Clinical Endocrinology. 2018; (89): 251-268. https://doi.org/10.1111/cen.13795
11. Wang Zheng, Henk Groen, Astrid E.P. Cantineau, Tessa M. van Elten, Matty D.A. Karsten, Anne M. van Oers, Ben W.J. Mol, Tessa J. Roseboom, Annemieke Hoek. Dietary Intake, Eating Behavior, Physical Activity, and Quality of Life in Infertile Women with PCOS and Obesity Compared with Non-PCOS Obese Controls. Nutrients. 2021; 13(10): 3526. https://doi.org/10.3390/NU13103526
12. Alizadeh Sanaz, Shahideh Jahanian Sadatmahalleh, Fatemeh Razavinia, Mahnaz Bahri Khomami, Malihe Nasiri, Ashraf Moini, Saeideh Ziaei. Metabolic parameters in cord blood of neonate of mothers with obese and non-obese PCOS and controls: retrospective cohort study. BMC Pregnancy and Childbirth. 2021; (21): 223. https://doi.org/10.1186/S12884-021-03697-6
13. Ye Hong. A new interpretation of weight management and lifestyle intervention in polycystic ovary syndrome. Family planning and obstetrics and gynecology in China. 2020; 12(02): 3-4.
14. Dong Jin-feng, Jiang Jing, Zheng Tongtong. et al. Association of insulin resistance obesity and sex hormone levels with serum anti-Müllerian hormone levels in patients with polycystic ovary syndrome. Maternal and Child Health Care of China. 2021; 36(09): 2086-2089. https://doi.org/10.19829/j.zgfybj.issn.1001-4411.2021.09.042
15. Sezai Sahmay, Begum Aydogan Mathyk, Nigar Sofiyeva, Nil Atakul, Aslı Azemi, Tamer Erela. Serum AMH levels and insulin resistance in women with PCOS. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2018; (224): 159-164. https://doi.org/10.1016/j.ejogrb.2018.03.007
16. Tang Yuzhu. et al. A multicenter prospective study on the role of Internet online lifestyle intervention in the treatment of patients with polycystic ovary syndrome based on body composition measurement. Chinese Journal of Reproductive and Contraception. 2019; (03): 177-184.
17. Hajivandi Leila, Noroozi Mahnaz, Mostafavi Firoozeh. A comprehensive interventional program for promoting eating behaviors in adolescent girls with polycystic ovarian syndrome (PCOS): protocol for a mixed methods study. Reproductive Health. 2018; 15(1): 197 p. https://doi.org/10.1186/s12978-018-0652-y
18. Zhang Qiaoli. Interpretation of 2018 SOGC Polycystic Ovary Syndrome Induction Practice Guide. Chinese Journal of Reproductive and Contraception. 2020; (362): 695-700.
19. Dietz de Loos Alexandra LP., Jiskoot Geranne, Timman Reinier, Beerthuizen Annemerle, Busschbach Jan J.V., Laven Joop S.E. Improvements in PCOS characteristics and phenotype severity during a randomized controlled lifestyle intervention. Reproductive BioMedicine Online. 2021; 43(2): 298-309. https://doi.org/10.1016/j.rbmo.2021.05.008
20. Anupama Bahadur, Neha Verma, Rajlaxmi Mundhra, Latika Chawla, Megha Ajmani, Modalavalasa Swetha Sri, Shivaani Arora. Correlation of Homeostatic Model Assessment-Insulin Resistance, Anti-Mullerian Hormone, and BMI in the Characterization of Polycystic Ovary Syndrome. Cureus. 2021; 13(6): e16047. https://doi.org/10.7759/CUREUS.16047
©
This is an open article under the CC BY 4.0 license. Published by the National Medical Research Center for Rehabilitation and Balneology.
