Issue 23-5, 2024

Review

https://doi.org/10.38025/2078-1962-2024-23-5-97-107

Osteoplastic Biomaterials from Organic and Mineral Components of the Bone Matrix: a Literature Review

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1ORCIDPavel A. Markov,  1,*ORCIDPetr S. Eremin,  1ORCIDElena S. Berezkina,1ORCIDMarina V. Volkova, 1ORCIDIrina A. Usova,1ORCIDIlmira R. Gilmutdinova

1National Medical Research Center for Rehabilitation and Balneology, Moscow, Russia


ABSTRACT

INTRODUCTION. The bones of the human and animal have a unique ability to remodel. The ability to constantly renew bone tissue determines the healing of fractures and the adaptation of bones to mechanical loads. However, the process of bone self-healing is effective only for defects of non-critical size. In segmental and critical defects, endogenous stimulation of bone tissue regeneration is required. In this regard, there remains a need to design osteoplastic biomaterials with improved pro-regenerative action. Every year, new data appear that expand our understanding of the methods and mechanisms for stimulating bone tissue restoration using artifi cial osteoplastic materials. AIM. Characteristics of modern methods of constructing biomimetic materials from organic and mineral components of bone matrix.
MATERIALS AND METHODS. The literature review was conducted using the PubMed and ScienceDirect databases. Query dates — may–july 2024, query depth — 1965–2024.
MAIN CONTENT OF THE REVIEW. Effective use of bone polymers for the creation of biomimetic osteoplastic materials is possible only with an understanding of the principles of molecular-cellular interaction of biopolymers with bone cells and tissues. By now, it has been established that the ability of collagen to influence the functional activity of cells involved in the reparative regeneration of bone tissue is due to the presence of special patterns in its structure - binding sites with cellular receptors, which are formed by a specific sequence of amino acids in the collagen polypeptide chain. In the case of inorganic bone material, the functionally significant elements are the chemical composition and crystal structure of calcium phosphate salts. A current trend in the design of osteoplastic materials is to impart biomimetic properties to them. At the molecular level, this approach is implemented using as intrafibrillar and extrafibrillar mineralization of collagen fibrils. At the tissue and organ level, biomimicry is achieved through the use of three-dimensional bioprint ing technologies.
CONCLUSION. Thus, thanks to advances in biology, physics, chemistry and engineering sciences, it was possible to develop new tech nologies for designing osteoplastic materials that imitate the structure and function of native bone tissue. The use of biomaterials cre ated using biomimetics principles increases the efficiency of bone tissue damage restoration.

KEYWORDS: collagen, hydroxyapatite, tricalcium phosphates, biocomposite, bioceramics

FUNDING: The authors declare no external funding in the conduct of the study.

CONFLICT OF INTEREST: The authors declare no apparent or potential conflicts of interest related to the publication of this article.

FOR CITATION:  Markov P.A., Eremin P.S., Berezkina E.S., Volkova M.V., Usova I.A., Gilmutdinova I.R. Osteoplastic Biomaterials from Organic and Mineral Components of the Bone Matrix: a Literature Review. Bulletin of Rehabilitation Medicine. 2024; 23(5):97-107. https://doi.org/10.38025/2078-1962-2024-23-5-97-107 (In Russ.).

FOR CORRESPONDENCE:

Petr S. Eremin, E-mail: ereminps@gmail.com, EreminPS@nmicrk.ru


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