Issue 23-6, 2024

Original article

https://doi.org/10.38025/2078-1962-2024-23-6-38-44

The Effect of Natural Mineral Water on Regulators of Gastroduodenal Motility in Young Adults: a Comparative Controlled Study

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1,* ORCIDAleksey Е. Shklyaev,1 ORCID Daniil D. Kazarin,1 ORCIDKirill V. Maksimov

1 Izhevsk State Medical Academy, Izhevsk, Russia


ABSTRACT

INTRODUCTION. Drinking balneotherapy has long been successfully used for pathologies of the digestive system. However, the sanogenetic mechanisms of normalization of gastrointestinal motility when using drinking mineral waters have not been sufficiently studied.
AIM. To assess the dynamics of the level of hormones that regulate gastric motility with a single dose of moderately mineralized sulfate-sodium-calcium mineral water in a young adults to reveal their sanogenetic role in functional dyspepsia.
MATERIALS AND METHODS. 3 groups were formed: the first — 57 people with postprandial distress syndrome (PDS), the second — 57 with epigastric pain syndrome (EPS), the third — 56 healthy people. All subjects were assessed for gastroenterological symptoms using a specific validated Gastrointestinal Symptom Rating Scale (GSRS) questionnaire, and the levels of motilin and cholecystokinin in the blood were determined before and after taking 200 ml of mineral water.
RESULTS. The level of motilinemia in patients with PDS initially (9811.67 ± 48.34 pg/ml) did not have significant differences from the level of healthy people (9665.64 ± 106.94 pg/ml) (p = 0.379), with EPS it was lower (8780.67 ± 102.94 pg/ml) (p = 0.000). In healthy people, the concentration of motilin in the blood after taking mineral water did not undergo statistically significant changes (p = 0.59), in patients with PDS it led to a decrease in its level by 13.8 % (p = 0.000), in patients with EPS it increased by 9.3 % (p = 0.000). The value of cholecystokininemia in EPS (180.6 ± 5.83 pg/ml) turned out to be statistically significantly higher (p = 0.008), and in PDS (116.67 ± 3.32 pg/ml) lower (p = 0.000) than in healthy group (146.64 ± 6.24 pg/ml). After drinking mineral water, healthy people experienced an increase in cholecystokininemia by 21.5 % (p = 0.003), in the group of patients with PDS — by 43.6 % (p = 0.000), with EPS — without significant dynamics (p = 0.491).
CONCLUSION. Features of the dynamics of the level of motilin and cholecystokinin in the blood of healthy people and with functional dyspepsia in response to a single dose of mineral water were revealed, which play an important role in the sanogenetic effect of drinking balneotherapy for gastric motility disorders.


KEYWORDS: drinking balneotherapy, mineral waters, postprandial distress syndrome, epigastric pain syndrome, motilin, cholecystokinin

FUNDING: The authors declare no external funding in the conduct of the study.

CONFLICT OF INTEREST: The authors declare no apparent or potential conflicts of interest related to the publication of this article.

FOR CITATION:

For citation: Shklyaev A.E., Kazarin D.D., Maksimov K.V. The Effect of Natural Mineral Water on Regulators of Gastroduodenal Motility in Young Adults: a Comparative Controlled Study. Bulletin of Rehabilitation Medicine. 2024; 23(6):38-44. https://doi.org/10.38025/2078-1962-2024-23-6-38-44 (In Russ.).

FOR CORRESPONDENCE:

Aleksey Е. Shklyaev, Е-mail: shklyaevaleksey@gmail.com, rector@igma.udm.ru


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This is an open article under the CC BY 4.0 license. Published by the National Medical Research Center for Rehabilitation and Balneology.