Оригинальная статья
Lung Pathology in Patients with Acute Respiratory Distress Syndrome Associated with the Novel SARS-Cov-2 Virus
1 Barberán J., 2 Ortiz G., 3 Cardinal-Fernández P.
1 HM Monteprincipe University Hospital, San Pablo CEU University. Madrid, Spain
2 Universidad del Bosque. Bogotá, Colombia
3 HM Sanchinarro University Hospital, HM International Department. Madrid, Spain
Резюме:
Acute Respiratory Distress Syndrome (ARDS) is a well-recognized clinical problem first described in the late sixties. However,its relevance seems to have increased since the severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) outbreak,as 14% (CI 95% 2% to 59%) of patients admitted to the hospital present with this syndrome.Conceptually, a syndrome is a group of symptoms and signs that correspond to several diseases. Although defining diseaseis much harder than may appear at first glance, we can view it as the association between a syndrome and a pathologypattern. Diffuse alveolar damage (DAD) is the morphological hallmark of ARDS, although studies performed inautopsies and patients have demonstrated that it is present in only half of ARDS patients. The SARS-CoV-2 outbreak andthe high incidence of ARDS associated with this infection have triggered a natural question: is the lung pathology similarin patients with ARDS associated with traditional risk factors than to SARS-CoV-2 infection?This review aims to analyze the lung pathology results of patients infected with the novel SARS-Cov-2. As this article targetsnon-intensive care physicians, we will first describe the main characteristics of the novel SARS-Cov-2 and the ARDSdefinition, and then the lung pathology results from the UCI in this group of patients.
Ключевые слова: coronavirus, SARS-Cov-2 infection, lung pathology, acute respiratory distress syndrome
Для цитирования: Barberán J., Ortiz G., Cardinal-Fernández P. Lung Pathology in Patients with Acute Respiratory Distress Syndrome Associated with the Novel SARS-Cov-2 Virus. Bulletin of Rehabilitation Medicine. 2020; 4 (98): 109–113. https://doi.org/10.38025/2078-1962-2020-98-4-109-113
Список литературы:
- Ashbaugh D.G., Bigelow D.B., Petty T.L., Levine B.E. Acute respiratory distress in adults. Lancet. 1967; 2(7511): 319-323.
- Rubenfeld G.D., Caldwell E., Peabody E., Weaver J., Martin D.P., Neff M., et al. Incidence and outcomes of acute lung injury. The New England Journal of Medicine. 2005; 353(16): 1685-1693.
- Potere N., Valeriani E., Candeloro M., Tana M., Porreca E., Abbate A., et al. Acute complications and mortality in hospitalized patients with coronavirus disease 2019: a systematic review and meta-analysis. Critical Care. 2020; 24(1): 389 p.
- Cardinal-Fernandez P., Correger E., Villanueva J., Rios F. Acute Respiratory Distress: from syndrome to disease. Medicina Intensiva. 2016; 40(3): 169-175.
- Katzenstein A.L., Bloor C.M., Leibow A.A. Diffuse alveolar damage--the role of oxygen, shock, and related factors. A review. The American Journal of Pathology. 1976; 85(1): 209-228.
- Force A.D.T., Ranieri V.M., Rubenfeld G.D., Thompson B.T., Ferguson N.D., Caldwell E., et al. Acute respiratory distress syndrome: the Berlin Definition. JAMA. 2012; 307(23): 2526-2533.
- Cardinal-Fernandez P., Bajwa E.K., Dominguez-Calvo A., Menendez J.M., Papazian L., Thompson B.T. The Presence of Diffuse Alveolar Damage on Open Lung Biopsy Is Associated With Mortality in Patients With Acute Respiratory Distress Syndrome: A Systematic Review and Meta-Analysis. Chest. 2016; 149(5): 1155-1164.
- Cardinal-Fernandez P., Ortiz G., Chang C.H., Kao K.C., Bertreau E., Philipponnet C., et al. Predicting the Impact of Diffuse Alveolar Damage through Open Lung Biopsy in Acute Respiratory Distress Syndrome-The PREDATOR Study. Journal of Clinical Medicine. 2019; 8(6).
- Zumla A., Chan J.F., Azhar E.I., Hui D.S., Yuen K.Y. Coronaviruses - drug discovery and therapeutic options. Nature Reviews Drug Discovery. 2016; 15(5): 327-347.
- Mohanty S.K., Satapathy A., Naidu M.M., Mukhopadhyay S., Sharma S., Barton L.M., et al. Severe acute respiratory syndrome coronavirus-2 (SARS-Cov-2) and coronavirus disease 19 (COV-ID-19) - anatomic pathology perspective on current knowledge. Diagnostic Pathology. 2020; 15(1): 103 p.
- Zhou P., Yang X.L., Wang X.G., Hu B., Zhang L., Zhang W., et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020; 579(7798): 270-273.
- Wang D., Hu B., Hu C., Zhu F., Liu X., Zhang J., et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA. 2020.
- Ferguson N.D., Fan E., Camporota L., Antonelli M., Anzueto A., Beale R., et al. The Berlin definition of ARDS: an expanded rationale, justification, and supplementary material. Intensive Care Medicine. 2012; 38(10): 1573-1582.
- Forel J.M., Guervilly C., Hraiech S., Voillet F., Thomas G., Somma C., et al. Type III procollagen is a reliable marker of ARDS-associated lung fibroproliferation. Intensive Care Medicine. 2015; 41(1): 1-11.
- Lorente J.A., Cardinal-Fernandez P., Munoz D., Frutos-Vivar F., Thille A.W., Jaramillo C., et al. Acute respiratory distress syndrome in patients with and without diffuse alveolar damage: an autopsy study. Intensive Care Medicine. 2015; 41(11): 1921-1930.
- Rios F., Iscar T., Cardinal-Fernandez P. What every intensivist should know about acute respiratory distress syndrome and diffuse alveolar damage. The Revista Brasileira de Terapia Intensiva. 2017; 29(3):354-363.
- Cardinal-Fernandez P., Lorente J.A., Ballen-Barragan A., Matute-Bello G. Acute Respiratory Distress Syndrome and Diffuse Alveolar Damage. New Insights on a Complex Relationship. Annals of the American Thoracic Society. 2017; 14(6): 844-850.
- Cardinal-Fernandez P., Esteban A., Thompson B.T., Lorente J.A. ARDS: lessons learned from the heart. Chest. 2015; 147(1): 7-8.
- Magro C., Mulvey J.J., Berlin D., Nuovo G., Salvatore S., Harp J., et al. Complement associated microvascular injury and thrombosis in the pathogenesis of severe COV-ID-19 infection: A report of five cases. Translational Research. 2020; (220): 1-13.
- Menter T., Haslbauer J.D., Nienhold R., Savic S., Hopfer H., Deigendesch N., et al. Postmortem examination of COV-ID-19 patients reveals diffuse alveolar damage with severe capillary congestion and variegated findings in lungs and other organs suggesting vascular dysfunction. Histopathology. 2020.
- Barnes B.J., Adrover J.M., Baxter-Stoltzfus A., Borczuk A., Cools-Lartigue J., Crawford J.M., et al. Targeting potential drivers of COV-ID-19: Neutrophil extracellular traps. Journal of Experimental Medicine. 2020; 217(6).
- Rothberg M.B., Haessler S.D. Complications of seasonal and pandemic influenza. Critical Care Medicine. 2010; 38(S.4): e91-7.
- Liao S.C., Shao S.C., Chen Y.T., Chen Y.C., Hung M.J. Incidence and mortality of pulmonary embolism in COV-ID-19: a systematic review and meta-analysis. Critical Care. 2020; 24(1): 464 p.
- Fogarty H., Townsend L., Ni Cheallaigh C., Bergin C., Martin-Loeches I., Browne P., et al. More on COV-ID-19 coagulopathy in Caucasian patients. British Journal of Haematology. 2020; 189(6): 1060-1061.
- Carsana L., Sonzogni A., Nasr A., Rossi R.S., Pellegrinelli A., Zerbi P., et al. Pulmonary post-mortem findings in a series of COV-ID-19 cases from northern Italy: a two-centre descriptive study. The Lancet Infectious Diseases. 2020.
- Fox S.E., Akmatbekov A., Harbert J.L., Li G., Quincy Brown J., Vander Heide R.S. Pulmonary and cardiac pathology in African American patients with COVID-19: an autopsy series from New Orleans. The Lancet Respiratory Medicine. 2020; 8(7): 681-686.