Оригинальная статья

Effect of Treatment with Silver Sulfate on the Physiological Effects of Natural Mineral Water

1 Lo Ying, 2 ORCIDLobanov A.A., 2 ORCIDAndronov S.V., 2 ORCIDZaitsev A.R., 2 ORCIDKochetkova V.M., 2 ORCIDFesyun A.D., 2 Zharkov A.I., 2 Fedotova M.Yu., 2 Parfenov A.A., 2 Kalmykov G.А., 3 ORCIDBogdanova E.N., 4 Sidorov V.V., 5 ORCIDPoskotinova L.V., 2 ORCIDYakovlev M.Yu., 2 ORCIDRachin A.P., 2 Voronenko A.G.

1 Guangdong University of Foreign Studies South China Business College, China, Guangdong
2 National Medical Center for Rehabilitation and Balneology, Russian Federation, Moscow
3 Northern Arctic Federal University, Russian Federation, Arkhangelsk
4 RPE «LAZMA», Russian Federation, Moscow
5 Federal Center for Integrated Arctic Research of the Russian Academy of Sciences, Russian Federation, Arkhangelsk


The treatment of mineral water with silver allows to significantly extend its shelf life without deteriorating its organolepticproperties, which makes it possible to use mineral water away from the natural deposit and is critical for businessand the end consumer. However, possible changes in the physiological properties of mineral waters when treated withsilver have not been studied until now. We have carried out a preclinical double-blind randomized placebo-controlled,experimental study, during which the effect of treatment with silver sulfate at a dose of 0.02 mg / liter (according to theEAEU tR 044–2017 regulation) of natural mineral water of sulphate-hydrocarbonate calcium-sodium (Russia, Stavropolterritory, deposit “Slavyanovskaya”, well No. 69 bis) for cellular metabolism, microcirculation and micro-lymphocyte whenapplied externally to the area of the inner surface of the forearm. A comparison of the effect on cell metabolism and microcirculationhas been made for applications with native mineral water “Slavyanovskaya”, “Slavyanovskaya, enriched withsilver sulfate” and placebo (tap water) after 30 minutes and after 24 hours. Number of patients: 15. Number of studies bylocation: 45. the results were monitored using the LAZMA St device. the study carried out simultaneous registration of diagnosticparameters of blood microcirculation, lymph microcirculation, as well as fluorescence amplitudes of coenzymesparticipating in oxidative metabolism - reduced nicotinamide adenine dinucleotide (NADH) and oxidized flavin adeninedinucleotide (FAD). It was revealed that the mineral water “Slavyanovskaya enriched with silver” differs in its physiologicaleffect on cellular metabolism, microcirculation and micro-lymph flow from the physiological effect of the mineral water“Slavyanovskaya”, namely that, compared to “Slavyanovskaya”, the mineral water “Slavyanovskaya enriched with silver”has a more pronounced positive effect on cellular metabolism, metabolic reserves of the cell, promotes the activation ofmicrocirculation and micro-lymphatic flow. Mineral water “Slavyanovskaya, enriched with silver” has a longer effect oncellular metabolism, microcirculation and micro-lymphatic flow than mineral water “Slavyanovskaya”. A statistically significantpositive effect of cell metabolism activation was detected both 30 minutes and 24 hours after exposure.Thus, this method of processing mineral water with silver sulfate not only does not decrease its positive physiological effect,but also improves it, prolonging its action, which makes further use of silver preparations in the processing of mineralwater justified.

Ключевые слова: mineral water, spa treatment, prevention, cell metabolism, microcirculation, laser fluorimetry

Для цитирования: Lo Ying, Lobanov A.A., Andronov S.V., Zaitsev A.R., Kochetkova V.M., Fesyun A.D., Zharkov A.I., Fedotova M.Yu., Parfenov A.A., Kalmykov G.А., Bogdanova E.N., Sidorov V.V., Poskotinova L.V., Yakovlev M.Yu., Rachin A.P., Voronenko A.G. Effect of treatment with Silver Sulfate on the Physiological Effects of Natural Mineral Water. Bulletin of Rehabilitation Medicine. 2020; 4 (98): 114–123. https://doi.org/10.38025/2078-1962-2020-98-4-114-123

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