Issue №3-91, 2019

Cytogenetic status of the person and efficacy of multivitamins

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1 Burobina A.V., 2 Sycheva L.P., 3 Truhanov A.I., 1 Zhuchenko N.A., 1 Asanov A.Y.

1 I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia
2 Russian State Research Center – Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, Moscow, Russia
3 ASVOMED Group, Moscow, Russia


ABSTRACT

The mechanism of action is many mutagens prooxidant as antimutagens began studying vitamins having an antioxidantaction, such as vitamins A and C. The basic method of evaluation of the status of a human cytogenetic analysis ofchromosome aberrations in peripheral blood lymphocytes. However, as an alternative to assess chromosomal damage areincreasingly using non-invasive (no blood sampling) micronucleus method in the epithelial cells of the buccal mucosa. In thiswork to study the influence reception recommended preventive doses “Helvesana”, having antioxidant and adaptogenicproperties Ratios cytogenetic status and cell kinetics of somatic cells on human health (buccal epithelial cells). As one of themechanisms for the induction of mutations in cells treated organism intracellular free radical formation under the influenceof chemical, physical or biological factors. The study was conducted using an innovative non-invasive test multiple organkariologichnskogo FCT, allowing to take into account a wide range of cytogenetic indices, indices of proliferation and destructionof cell nuclei. When comparing figures karyological buccal donor before and after drug administration “Helvesana”the tendency to reduce the frequency with cytogenetic impaired cell proliferation and indices normalization condition buccalRatios nucleus degradation.Statistically significant differences were revealed for the proportion of cells with a perinuclearvacuole, and karyorrhexis karyolysis complete. For most of the participants in the survey after ingestion “Helvesana” markedimprovement of cytogenetic status. The new disease prevention paradigm based on the personalized prevention of DNAdamage, on the agenda is the question of the implementation of micronucleus test to assess the efficacy and safety of naturaland synthetic antimutagens.


KEYWORDS: Mutagens, vitamins, chromosomal aberration, antioxidants, adaptogens cytogenetic status, buccal epithelial cells, karyological test perinuclear vacuole, karyorrhexis, karyolysis, free radicals, micronucleus test, the genetic status.



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