Issue №20-4, 2021

Original article

https://doi.org/10.38025/2078-1962-2021-20-4-35-42

Application of Piracetam Electrophoresis in Complex Sanatorium-Resort Treatment of Girls with Amenorrhea

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1 ORCIDOlga I. Garmash, 2 Natalya V. Kosolapova, 1 ORCIDOlga F. Gavrilova

1 Research Institute of Children’s Balneology, Physiotherapy and Medical Rehabilitation, Evpatоria, Russian Federation
2 V.I. Vernadsky Crimean Federal University, Simferopol, Russian Federation


ABSTRACT

AIM. The aim of this work was to study the effectiveness of the piracetam electrophoresis application in the complex sanatoriumresorttreatment of girls with amenorrhea.

MATERIAL AND METHODS. 56 girls aged 12 to 17 years were under observation, who were treated in the gynecological department ofthe children’s clinical sanatorium “Zdravnitsa”. Primary amenorrhea was recorded in 15 girls, secondary amenorrhea in 41. Long-termresults of sanatorium-resort treatment were studied in 8 girls with secondary amenorrhea. The control group consisted of 20 healthygirls, comparable in age, who underwent hormonal studies.

RESULTS. Upon admission to the sanatorium, the main complaint of all girls was the absence of menstruation, many had chronicinflammatory pathology of the ENT organs and pathology of the musculoskeletal system. There was a decrease in ovarian steroidogenesis,while hypoestrogenism was observed in the majority of patients. Girls with amenorrhea are characterized by a high levelof vertigo, an average level of anxiety, fatigue and a fairly low level of irritability. After the sanatorium-resort treatment, an improvementin the general condition of the girls was noted; during their stay in the sanatorium, menstruation was observed in 4 girls withsecondary amenorrhea. After the treatment, a significant positive dynamics of steroid and peptide hormones was revealed in girlswith primary and secondary amenorrhea. In girls with secondary amenorrhea, the ratio of LH/FSH approached the physiological one,but remained significantly higher than normal indicators. Under the influence of sanatorium-resort treatment, the level of adrenalinein the urine normalized in all girls with primary amenorrhea, and in the majority with secondary amenorrhea. There was a positivedynamics of the girls’ psycho-emotional state. According to the long-term results data of sanatorium-resort treatment, the restorationof menstrual function was observed within a year in half of the girls with secondary amenorrhea.

CONCLUSION. The use of the 5% piracetam solution electrophoresis in a complex sanatorium-resort treatment of girls with amenorrheaimproved the general health of girls, normalized hormonal levels and restored menstrual function in half of the girls with secondaryamenorrhea within a year after a course of treatment in the sanatorium.


KEYWORDS: pediatric gynecology, girls, primary and secondary amenorrhea, sanatorium-resort treatment, transcerebral electrophoresis of piracetam

Acknowledgments: The study had no sponsorship

Conflict of interest:: The authors declare no apparent or potential conflicts of interest related to the publication of this article

For citation: Garmash O.I., Kosolapova N.V., Gavrilova O.F. Application of Piracetam Electrophoresis in Complex Sanatorium-Resort Treatment of Girls with Amenorrhea. Bulletin of Rehabilitation Medicine. 2021; 20 (4): 35-42. https://doi.org/10.38025/2078-1962-2021-20-4-35-42

For correspondence: Olga I. Garmash, e-mail: olgadimalex@list.ru



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