Issue 25-1, 2026

Original article

https://doi.org/10.38025/2078-1962-2026-25-1-29-39

Effectiveness of Endonasal Cortexin Electrophoresis and VR-Technology in Visual Impairment after Ischemic Stroke: Perimetry Data Analysis

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ORCIDTatiana V. Marfina*, ORCIDTatiana V. Konchugova, ORCIDAnastasiya A. Mukhina, ORCIDTatiana V. Apkhanova

National Medical Research Center for Rehabilitation and Balneology, Moscow, Russia


ABSTRACT

INTRODUCTION.  Visual field disorders are a prevalent complication following a stroke, affecting up to 45–65 % of patients in this category. These disorders significantly impair the quality of life of affected individuals, underscoring the need for early and accurate diagnosis, as well as the development of effective rehabilitation methods aimed at restoring visual functions and improving functional outcomes.

AIM.   To evaluate the effectiveness of a comprehensive rehabilitation program using endonasal Cortexin electrophoresis and virtual reality technology in patients with post-stroke visual impairments based on the analysis of perimeter parameters.

MATERIALS AND METHODS.   The study included 60 patients aged 36 to 73 years who were in the second stage of medical rehabilitation after ischemic stroke and had peripheral vision disorders caused by cerebral damage. The patients were randomized into 3 groups, consisting of 20 participants each: the control group received basic rehabilitation; the comparison group received basic rehabilitation in addition to Virtual Reality technology; and the treatment group received the same rehabilitation programme as the comparison group, in addition to undergoing endonasal electrophoresis of Cortexin. Visual field evaluations were conducted prior to and following the course using the Tomey AP-3000 automatic perimeter.

RESULTS.   There were no statistically significant changes in the control group. In the comparison group, and especially in the main group, there was a significant improvement in both the overall visual field (OVF) and the static perimeter parameters (average photosensitivity, AD and PD). The main group showed a maximum increase in the OVF (32.59 degrees for white and 49.43 degrees for red stimuli) and a significant improvement in all three perimeter parameters, including a decrease in PD, indicating an increase in the functional uniformity of the visual field.

DISCUSSION.   The intergroup analysis confirmed the statistically significant superiority of both experimental groups over the control group in terms of the dynamics of OVF and perimetric parameters (p < 0.017), while the main group was superior to the comparison group with regard to the degree of improvement.

CONCLUSION.   The results confirmed the high effectiveness of the combined rehabilitation program in restoring visual functions in patients with post-stroke peripheral vision disorders. Kinetic perimetry proved to be a convenient screening tool, whereas static perimetry was found to be preferable for detailed monitoring of the rehabilitation progress.


KEYWORDS: stroke, post-stroke visual disturbances, visual field, homonomous hemianopia, perimetry

FOR CITATION: Marfina T.V., Konchugova T.V., Mukhina A.A., Apkhanova T.V. Effectiveness of Endonasal Cortexin Electrophoresis and VR-Technology in Visual Impairment after Ischemic Stroke: Perimetry Data Analysis. Bulletin of Rehabilitation Medicine. 2026; 25(1):29–39. https://doi.org/10.38025/2078-1962-2026-25-1-29-39 (In Russ.).

FOR CORRESPONDENCE:

Tatiana V. Marfina, E-mail:  marfinatv@nmicrk.ru


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This is an open article under the CC BY 4.0 license. Published by the National Medical Research Center for Rehabilitation and Balneology.