Issue 25-4, 2026

Original article

Clinical and Functional Rationale for the Use of Non-Pharmacological Treatment in Patients with Visual Impairments after Stroke: A Single-Center Controlled Trial



ORCIDKristina M. Nazarova*, ORCIDSvetlana I. Nareiko, ORCIDTatiana V. Marfina, ORCIDTatiana V. Konchugova, ORCIDLev G. Agasarov, ORCIDNatalia N. Zubareva, ORCIDLarisa A. Marchenkova

National Medical Research Center for Rehabilitation and Balneology, Moscow, Russia


ABSTRACT

INTRODUCTION. Each year, over 12 million new stroke cases are reported globally, with up to 50 % of survivors experiencing persistent neurological deficits. The most common among these deficits is post-stroke spasticity. The incidence of spasticity ranges from 20 to 40 % during the early rehabilitation period, and increases to 50–60 % among patients with hemiparesis in the later stages following a stroke. It is important to emphasize that a patient’s recovery after a stroke should not be limited solely to addressing motor impairments.

AIM. To evaluate the effect of a comprehensive program combining reflexology and occupational therapy on spasticity and functional mobility, with a focus on short-term outcomes and quality of life in patients with post-stroke spasticity and visual impairments.

MATERIALS AND METHODS. A single-centre controlled study included 40 patients in the early recovery phase of an ischaemic stroke (up to 6 months) with spasticity rated 1–3 on the modified Ashworth scale and objectively confirmed visual impairments. The main group, in addition to standard health resort treatment, received a course of reflexotherapy (10 sessions) and occupational therapy (10 sessions). Alongside traditional scales (the Modified Ashworth Scale (MAS), the Barthel Index, the Quality of Life Assessment (EQ-5D-5L) and others), particular attention was paid to timed tests — the Timed Up & Go test and the time taken to perform basic self-care tasks. The study was conducted in the premises of the National Medical Research Centre for Rehabilitation and Balneology of the Russian Ministry of Health, between 2024 and 2026.

RESULTS. The intervention group demonstrated a significant reduction in spasticity (MAS from 2 [1; 3] to 1 [1; 2] points; p = 0.001) and marked improvement in temporal mobility measures: Timed Up and Go test time decreased from 25.0 [22.5; 28.0] to 22.0 [20.0; 25.0] sec (p = 0.02), while the duration of dressing and eating tasks decreased by an average of 25–30 %. Furthermore, daily living independence rose (Barthel Index from 65 to 85 points; p = 0.0004), quality of life (EQ-5D-5L) improved, and anxiety-depressive symptoms decreased (Hospital Anxiety and Depression Scale (HADS); p < 0.01). No adverse events were recorded.

DISCUSSION. The use of reflexology and occupational therapy is accompanied by an improvement in the quality of life, a decrease in anxiety and depression, as well as a decrease in pain, which indicates a systemic positive effect on the psycho-emotional status and quality of life of patients. Therefore, the proposed program is characterized by high safety (there were no adverse events) and good tolerability, which makes it possible to recommend it for widespread implementation in health resort institutions providing medical rehabilitation to patients after a stroke.

CONCLUSION. The combined use of reflexotherapy and occupational therapy in patients with post-stroke spasticity and visual impairments is a safe and effective method that not only reduces muscle tone but also significantly improves temporal characteristics of motor activity and everyday independence. These findings justify the inclusion of this programme in the standards for health resort rehabilitation to address both motor and time-related functional impairments.


KEYWORDS: stroke, spasticity, reflexology, occupational therapy, health-resort treatment, rehabilitation, daily activity, quality of life, visual impairment

FOR CITATION: Nazarova K.M., Nareiko S.I., Marfina T.V., Konchugova T.V., Agasarov L.G., Zubareva N.N., Marchenkova L.A. Clinical and Functional Rationale for the Use of Non-Pharmacological Treatment in Patients with Visual Impairments after Stroke: A Single-Center Controlled Trial. Bulletin of Rehabilitation Medicine. 2026; 25(4):45–53.https://doi.org/10.38025/2078-1962-2026-25-4-45-53 (In Russ.).

FOR CORRESPONDENCE:

Kristina M. Nazarova, E-mail: nazarovakm@nmicrk.ru


References:

  1. Wissel J., Manack A., Brainin M. Toward an epidemiology of poststroke spasticity. Neurology. 2013. 80(3_suppl_2): S13–S19. https://doi.org/10.1212/wnl.0b013e3182762448
  2. Benjamin E.J., Blaha M.J., Chiuve S.E., et al. Heart disease and stroke statistics — 2017 update: A Report From the American Heart Association. Circulation. 2017; 135(10): e146–e603. https://doi.org/10.1161/cir.0000000000000485
  3. Raggi A., Serretti A., Ferri R. A comprehensive overview of post-stroke depression treatment options. International Clinical Psychopharmacology. 2024; 39(3): 127–138. https://doi.org/10.1097/yic.0000000000000532
  4. Zorowitz R.D., Gillard P.J., Brainin M. Poststroke spasticity: sequelae and burden on stroke survivors and caregivers. Neurology. 2013; 80(3_suppl_2): S45–S52. https://doi.org/10.1212/wnl.0b013e3182764c86
  5. Агасаров Л.Г. Руководство по рефлексотерапии: учебное пособие. М.: Арнебия. 2001: 304. [Agasarov L.G. Guide to Reflexotherapy: A Textbook. Moscow: Arnebia. 2001; 304 (In Russ.).]
  6. Министерство здравоохранения Российской Федерации. Рубрикатор клинических рекомендаций. Клинические рекомендации «Ишемический инсульт и транзиторная ишемическая атака». 20.11.2024. Доступно на: https://cr.minzdrav.gov.ru/preview-cr/814_1 (дата обращения 01.07.2025). [Ministry of Health of the Russian Federation. The Clinical Guidelines Rubricator. Clinical Guidelines “Ischemic Stroke and Transient Ischemic Attack”. November 20, 2024. Available from: https://cr.minzdrav.gov.ru/preview-cr/814_1 (Accessed July 1, 2026) (In Russ.).]
  7. Ворона С.А., Кабыш С.С., Можейко Е.Ю. и др. Возможности восстановления в дистанционном формате пациентов, перенесших ишемический инсульт, с комплексной моторной афазией: обзор. Вестник восстановительной медицины. 2025; 24(6): 82–90. https://doi.org/10.38025/2078-1962-2025-24-6-82-90 [Vorona S.A., Kabysh S.S., Mozheiko E.Yu., et al. Remote Rehabilitation Potential for Ischemic Stroke Patients with Complex Motor Aphasia: a Review. Bulletin of Rehabilitation Medicine. 2025; 24(6): 82–90. https://doi.org/10.38025/2078-1962-2025-24-6-82-90 (In Russ.).]
  8. Кузюкова А.А., Одарущенко О.И., Загайнова А.Ю. и др. Цереброваскулярные заболевания и приверженность: когнитивный барьер на пути к целям лечения. Обзор литературы. Вестник восстановительной медицины. 2025; 24(6): 118–130. https://doi.org/10.38025/2078-1962-2025-24-6-118-130 [Kuzyukova A.A., Odarushchenko O.I., Zagaynova A.Yu., et al. Cerebrovascular Diseases and Adherence: a Cognitive Barrier to Achieving Treatment Goals. A Literature Review. Bulletin of Rehabilitation Medicine. 2025; 24(6): 118–130. https://doi.org/10.38025/2078-1962-2025-24-6-118-130 (In Russ.).]
  9. Скворцов Д.В., Кауркин С.Н., Иванова Г.Е. и др. Эффективность тренировки ходьбы по электромиограмме у пациентов с инсультом: экспериментальное продольное пилотное исследование. Вестник восстановительной медицины. 2025; 24(1): 8–18. https://doi.org/10.38025/2078-1962-2025-24-1-8-18 [Skvortsov D.V., Kaurkin S.N., Ivanova G.E., et al. Effectiveness of Gait Training with Electromyogram in Stroke Patients: an Experimental Longitudinal Pilot Study. Bulletin of Rehabilitation Medicine. 2025; 24(1): 8–18. https://doi.org/10.38025/2078-1962-2025-24-1-8-18 (In Russ.).]
  10. Петров К.Б., Митичкина Т.В. Постинсультные синкинезии: клинико-реабилитационные аспекты. Обзор. Вестник восстановительной медицины. 2025; 24(1): 75–83. https://doi.org/10.38025/2078-1962-2025-24-1-75-83 [Petrov K.B., Mitichkina T.V. Post-Stroke Synkinesis: Clinical and Rehabilitation Aspects. A Review. Bulletin of Rehabilitation Medicine. 2025; 24(1): 75–83. https://doi.org/10.38025/2078-1962-2025-24-1-75-83 (In Russ.).]
  11. He Q., Wang W., Zhang Y., et al. Global, regional, and national burden of stroke, 1990–2021: a systematic analysis for global burden of disease 2021. Stroke. 2024; 55(12): 2815–2824.
  12. Агасаров Л.Г. Рефлексотерапия при распространенных заболеваниях нервной системы. Москва. 2017; 240 с. [Agasarov L.G. Reflexotherapy for Common Diseases of the Nervous System. Moscow. 2017; 240 p. (In Russ.).]
  13. Марфина Т.В., Кончугова Т.В., Мухина А.А., Апханова Т.В. Эффективность эндоназального электрофореза Кортексина и технологии виртуальной реальности при нарушениях зрения после ишемического инсульта: анализ данных периметрии. Вестник восстановительной медицины. 2026; 25(1): 29–39. https://doi.org/10.38025/2078-1962-2026-25-1-29-39 [Marfina T.V., Konchugova T.V., Mukhina A.A., Apkhanova T.V. Efficacy of Endonasal Electrophoresis of Cortexin and Virtual Reality Technology for Visual Impairments After Ischemic Stroke: Analysis of Perimetry Data. Bulletin of Rehabilitation Medicine. 2026; 25(1): 29–39. https://doi.org/10.38025/2078-1962-2026-25-1-29-39 (In Russ.).]
  14. He J.L., Ma L.X., Wen J.S., et al. Potential impacts of acupuncture on motor function recovery after ischemic stroke: insights from basic and clinical studies. Frontiers in Cellular Neuroscience. 2025; 19: 1623535. https://doi.org/10.3389/fncel.2025.1623535
  15. Thawisuk C., Inoue K., Suyama N., et al. Mapping Robotics and Occupation-Based Practice in Stroke Rehabilitation: A Scoping Review. OTJR: Occupational Therapy Journal of Research. 2025; 15394492251347160. https://doi.org/10.1177/15394492251347160
  16. Huang H., Chen J., Qiu F., et al. Effect of electroacupuncture on motor function and gait in patients with post-stroke spasticity in lower limbs. Zhongguo Zhen Jiu. 2022; 42(1): 23–27. https://doi.org/10.13703/j.0255-2930.20201201-k0004
  17. Lindsay C., Humphreys I., Phillips C., Pandyan A. Estimating the cost consequence of the early use of botulinum toxin in post-stroke spasticity: Secondary analysis of a randomised controlled trial. Clinical Rehabilitation. 2023; 37(3): 373–380. https://doi.org/10.1177/02692155221133522
  18. Назарова К.М., Налобина А.Н. Проблемы и перспективы развития эрготерапии в системе восстановительной медицины. Формы и методы социальной работы в различных сферах жизнедеятельности. Материалы ХIV Международной научно-практической конференции. Улан-Удэ: Восточно-Сибирский государственный университет технологий и управления. 2025; с. 79–81. [Nazarova K.M., Nalobina A.N. Problems and prospects of occupational therapy development in the system of restorative medicine. Forms and Methods of Social Work in Various Spheres of Life. Proceedings of the XIV International Scientific and Practical Conference. Ulan-Ude: East Siberian State University of Technology and Management. 2025; pp. 79–81 (In Russ.).]
  19. Назарова К.М. Эрготерапия в санаторно-курортной отрасли: новый вектор реабилитации и оздоровления. Санаторно-курортное лечение. Материалы XI Международного конгресса. М.: МЕДИ Экспо. 2025; с. 67–68. [Nazarova K.M. Occupational therapy in the sanatorium-resort industry: a new vector of rehabilitation and health improvement. Sanatorium-Resort Treatment. Proceedings of the XI International Congress. M.: MEDI Expo. 2025; pp. 67–68 (In Russ.).]
  20. Назарова К.М. Эрготерапия как ключ к функциональной независимости: внедрение в санаторно-курортную практику. Вопросы курортологии, физиотерапии и лечебной физической культуры. 2025; 102(3–2): 135. [Nazarova K.M. Occupational therapy as a key to functional independence: implementation in sanatorium-resort practice. Problems of Balneology, Physiotherapy and Exercise Therapy. 2025; 102(3–2): 135 (In Russ.).]
  21. Мусаева О.М., Назарова К.М. Комплексный метод реабилитации пациентов после перенесенного острого нарушения мозгового кровообращения, осложнившегося развитием гастроэзофагеальной рефлюксной болезни (клинический случай). Вопросы курортологии, физиотерапии и лечебной физической культуры. 2025; 102(3–2): 129–130. [Musaeva O.M., Nazarova K.M. A comprehensive method of rehabilitation of patients after acute cerebrovascular accident complicated by the development of gastroesophageal reflux disease (clinical case). Problems of Balneology, Physiotherapy and Exercise Therapy. 2025; 102(3–2): 129–130 (In Russ.).]
  22. Zhang R., Lao L., Ren K., Berman B.M. Mechanisms of acupuncture-electroacupuncture on persistent pain. Anesthesiology. 2014; 120(2): 482. https://doi.org/10.1097/aln.0000000000000101
  23. Zhao H., Lu Y., Wang Y., et al. Electroacupunture contributes to recovery of neurological deficits in experimental stroke by activating astrocytes. Restorative Neurology and Neuroscience. 2018; 36(3): 301–312. https://doi.org/10.3233/RNN-170722



Creative Commons License
The content is available under the Creative Commons Attribution 4.0 License.

©


This is an open article under the CC BY 4.0 license. Published by the National Medical Research Center for Rehabilitation and Balneology.